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Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length
- Source :
- Human Reproduction, 27(3), 867-872. Oxford University Press, Meijer, L, Martijn, A, Melessen, J, Brouwer, A, Weiss, J M, de Jong, F H & Sauer, P J J 2012, ' Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length ', Human Reproduction, vol. 27, no. 3, pp. 867-872 . https://doi.org/10.1093/humrep/der426
- Publication Year :
- 2012
-
Abstract
- Background Prenatal exposure to endocrine disruptors, like organohalogen compounds (OHCs), might be responsible for the increased aberrations in human male sexual development (hypospadias, cryptorchidism, testicular cancer and fall in sperm count) observed over the past decades. This development is established during fetal life, and reflected in sex hormone levels, testes volume and penile length post-partum. The present study investigates the correlation between prenatal OHC levels and male sexual development outcomes.Methods AND RESULTSLevels of eight neutral [2,2′-bis-(4-chlorophenyl)-1,1′- dichloroethene (4,4′-DDE), 2,2′,4,4′,5,5′- hexachlorobiphenyl, 2,2′,4,4′-tetrabromodiphenyl ether (BDE)-47,-99,-100,-153,-154 and 1,2,5,6,9,10-hexabromocyclododecane, HBCDD] and four phenolic [(pentachlorophenol (PCP), 4OH-CB-107 (4-hydroxy-2,3,3′, 4′,5-pentachlorobiphenyl),-146 and-187)] OHCs were determined in 55 maternal serum samples taken at 35 weeks of pregnancy. Eight sex development-related hormones [testosterone, free testosterone, sex hormone-binding globulin (SHBG); LH, FSH, estradiol (E2), free E2 (FE2) and inhibin B (InhB)] were determined in their sons at 3 months of age, and testes volume and penile length at 3 and 18 months of age. The following prenatal OHC levels correlated significantly with sex hormone levels: PCP with SHBG and InhB (ρ 0.30 and-0.43, respectively), 4OH-CB-107 with testosterone (ρ 0.31) and BDE-154 with FE2, E2 and InhB (ρ 0.49, 0.54 and 0.34, respectively). BDE-154 levels correlated positively with testes volume at 18 months of age (ρ 0.34). Conclusions Prenatal OHC exposure is correlated with aspects of sexual development outcome in boys up to 18 months of age. © 2012 The Author.
- Subjects :
- Male
BFR
Endocrine Disruptors
Cohort Studies
human sexual development
Sex hormone-binding globulin
Pregnancy
P,P-DDE
POLYCHLORINATED-BIPHENYLS
TESTOSTERONE
Testis
Gonadal Steroid Hormones
Testosterone
ASSOCIATIONS
PCB
Sexual Development
Rehabilitation
WOMEN
Obstetrics and Gynecology
MEN
P-DDE
Prenatal Exposure Delayed Effects
Female
medicine.medical_specialty
Pregnancy Trimester, Third
CB-153
Prenatal care
Biology
SDG 3 - Good Health and Well-being
Internal medicine
medicine
QUALITY
Endocrine system
Humans
SEMEN
TDS
Fetus
Hydrocarbons, Halogenated
organohalogen compounds
medicine.disease
SERUM CONCENTRATIONS
Endocrinology
Reproductive Medicine
Hypospadias
biology.protein
Hormone
Penis
Subjects
Details
- ISSN :
- 14602350 and 02681161
- Volume :
- 27
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Human reproduction (Oxford, England)
- Accession number :
- edsair.doi.dedup.....a28ebe2432baf60a4e696c99f29281fe