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Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics
- Source :
- Trends in Parasitology, Trends in Parasitology, 2020, 36, pp.616-633. ⟨10.1016/j.pt.2020.04.010⟩, Trends in Parasitology, Elsevier, 2020, 36, pp.616-633. ⟨10.1016/j.pt.2020.04.010⟩
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Microorganisms are increasingly recognized as ecosystem-relevant components because they affect the population dynamics of hosts. Functioning at the interface of the host and pathogen, skin and gut microbiomes are vital components of immunity. Recent work reveals a strong influence of biotic and abiotic environmental factors (including the environmental microbiome) on disease dynamics, yet the importance of the host-host microbiome-pathogen-environment interaction has been poorly reflected in theory. We use amphibians and the disease chytridiomycosis caused by the fungal pathogen Batrachochytrium dendrobatidis to show how interactions between host, host microbiome, pathogen, and the environment all affect disease outcome. Our review provides new perspectives that improve our understanding of disease dynamics and ecology by incorporating environmental factors and microbiomes into disease theory.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
Ecology (disciplines)
030106 microbiology
Population
Disease
Environment
Biology
Amphibians
03 medical and health sciences
Animals
Humans
Chytridiomycosis
Microbiome
education
Pathogen
Abiotic component
education.field_of_study
Ecology
Host (biology)
Microbiota
Chytridiomycota
030104 developmental biology
Infectious Diseases
Mycoses
Host-Pathogen Interactions
Parasitology
Subjects
Details
- ISSN :
- 14714922
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Trends in Parasitology
- Accession number :
- edsair.doi.dedup.....a285f9392dc866fda365b0fb9ca329fc