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Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway
- Source :
- Frontiers in Psychiatry, Frontiers in Psychiatry, Vol 9 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Neuronal damage is related to the onset and treatment of depressive disorders. Antidepressant-like effects have been elicited by paeoniflorin on animal models. The aim of this study is to demonstrate whether the neuroprotective effect of paeoniflorin on rats suffered from chronic unpredictable mild stress (CUMS) was regulated by the ERK-CREB signaling pathway. Results showed that paeoniflorin not only ameliorated depressive-like behavior with low locomotor activity and prolonged immobility duration in our forced swimming test but also reduced sucrose consumption. Paeoniflorin treatment decreased the degree of neuronal damage in the hippocampus of the model rats. Conversely, it markedly increased the mRNA levels of ERK1, ERK2, and CREB and the levels of ERK, p-ERK, CREB, and p-CREB protein expression in the hippocampus. Blockade of the ERK-CREB axis with the ERK-specific inhibitor U0126 repressed the neuroprotective and antidepressant-like effects of paeoniflorin on rats in the setting of chronic-mild-stress and abolished the recoveries of p-ERK mediated by paeoniflorin treatment. Thus, paeoniflorin possibly exerted a neuroprotective effect modulated by the ERK-CREB signaling pathway on CUMS-induced hippocampal damage in rats.
- Subjects :
- MAPK/ERK pathway
U0126
lcsh:RC435-571
Hippocampal formation
Pharmacology
CREB
Neuroprotection
03 medical and health sciences
chemistry.chemical_compound
paeoniflorin
0302 clinical medicine
ERK-CREB pathway
lcsh:Psychiatry
Hippocampus (mythology)
Chronic stress
Original Research
Psychiatry
biology
chronic mild stress
Paeoniflorin
030227 psychiatry
Psychiatry and Mental health
chemistry
biology.protein
neuroprotection
030217 neurology & neurosurgery
Behavioural despair test
Subjects
Details
- Language :
- English
- ISSN :
- 16640640
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Psychiatry
- Accession number :
- edsair.doi.dedup.....a2793d1df9079594525510aa66bf4132