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Serum KL-6 Concentrations in Dairy Farmers
- Source :
- Chest. 118:445-450
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Study objectives: Serum KL-6 (Krebs von den Lungen-6) has been recognized to be a marker for the activity of diffuse interstitial lung diseases. The purpose of the study is to evaluate serum KL-6 measurement as a marker for farmer’s lung disease (FLD). Design: A cross-sectional survey of a cohort of dairy farmers. Retrospective measurement of KL-6 stored serum samples from those dairy farmers previously screened for FLD. Setting: University hospital screening project for FLD within a dairy-farming community in Japan. Participants: Four hundred seventy-two dairy farmers were invited to attend a local clinic. Measurements and results: We examined serum KL-6 concentrations in 272 farmers. Subjects were classified into three groups: (1) 5 farmers with FLD, (2) 30 farmers with positive serum precipitating antibodies to Saccharopolyspora rectivirgula and/or Thermoactinomyces vulgaris without FLD (Ab 1 ), and (3) 237 farmers without these antibodies (Ab 2 ). Serum KL-6 concentrations in the FLD group were significantly higher than those in the Ab 1 and the Ab 2 groups (1,263 6 288 [SEM], 328 6 57, and 207 6 6 U/mL, respectively, p < 0.001). Serum KL-6 concentrations in those with FLD were significantly higher than KL-6 concentrations from stored screening samples from the same individual when FLD was not diagnosed (1,263 6 288 and 419 6 209 U/mL, respectively, p < 0.05). Serum KL-6 concentrations of the Ab 1 group were significantly higher than those of the Ab 2 group (p < 0.001). In the Ab 1 group, farmers with high serum KL-6 concentrations had lower permeability coefficients than farmers with normal serum KL-6 concentrations (p < 0.05). These results may suggest that subclinical FLD can be detected in farmers with high KL-6 concentrations and precipitating antibodies. Conclusion: Serum KL-6 concentration can be a useful marker for assessing the activity of FLD and may be able to be used to detect subclinical disease. (CHEST 2000; 118:445‐ 450)
- Subjects :
- Male
Rural Population
Pulmonary and Respiratory Medicine
Occupational disease
Critical Care and Intensive Care Medicine
Animal science
Japan
Antigens, Neoplasm
Occupational Exposure
Surveys and Questionnaires
Actinomycetales
Humans
Medicine
Thermoactinomyces vulgaris
Saccharopolyspora rectivirgula
Animal Husbandry
Antigens
Antibodies, Fungal
Glycoproteins
Retrospective Studies
Subclinical infection
biology
business.industry
Incidence
Incidence (epidemiology)
Mucin-1
fungi
Mucins
food and beverages
Middle Aged
biology.organism_classification
medicine.disease
University hospital
Peptide Fragments
respiratory tract diseases
Lung disease
Farmer's Lung
Immunology
Cohort
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Procollagen
Subjects
Details
- ISSN :
- 00123692
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Chest
- Accession number :
- edsair.doi.dedup.....a26c0556012ef1763845eeaf01568b31