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Impact of high neutrophil-to-lymphocyte ratio on the cardiovascular benefit of PCSK9 inhibitors in familial hypercholesterolemia subjects with atherosclerotic cardiovascular disease: Real-world data from two lipid units
- Publication Year :
- 2021
-
Abstract
- BACKGROUND AND AIMS Neutrophil-to-lymphocyte ratio (NLR) is a novel inflammatory biomarker strongly associated with atherosclerotic cardiovascular disease (ASCVD). Our aim was to evaluate the role of NLR on pulse wave velocity (PWV) after adding-on proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9-i) in familial hypercholesterolemia (FH) subjects with ASCVD. METHODS AND RESULTS In this prospective observational study, we evaluated 45 FH subjects with ASCVD on high-intensity statins plus ezetimibe and with an off-target LDL-C. Study population was divided into two groups according to the mean value of NLR. All patients received PCSK9-i therapy and obtained biochemical analysis as well as PWV evaluation at baseline and after six months of PCSK9-i. After six months of add-on PCSK9-i therapy, a significant reduction of TC, LDL-C, Non-HDL-C, Lp(a) and ApoB plasma levels was observed in the two groups; while low-NLR group exhibited a significant PWV reduction after six-month therapy with PCSK9-i (Δ -16.2%, p
- Subjects :
- medicine.medical_specialty
Apolipoprotein B
Neutrophils
Endocrinology, Diabetes and Metabolism
Familial hypercholesterolemia
Medicine (miscellaneous)
Pulse Wave Analysis
Hyperlipoproteinemia Type II
Ezetimibe
Internal medicine
medicine
Humans
Lymphocytes
Neutrophil to lymphocyte ratio
Pulse wave velocity
Neutrophil-to-lymphocyte ratio
Nutrition and Dietetics
biology
business.industry
PCSK9
Anticholesteremic Agents
fungi
PCSK9 Inhibitors
medicine.disease
Cardiovascular risk
Atherosclerosis
Inflammatory profile
Treatment Outcome
PCSK9 inhibitors
Cardiology
biology.protein
Population study
Observational study
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a266a3d0359c0a3012ba265ce0413bb0