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Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus
- Source :
- Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (5), pp.2938-2941. ⟨10.1128/aac.05080-14⟩
- Publication Year :
- 2015
- Publisher :
- American Society for Microbiology, 2015.
-
Abstract
- The production of β-lactamases Bla Mab and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis , respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.
- Subjects :
- Tuberculosis
Mycobacterium abscessus
beta-Lactamases
Mycobacterium
Microbiology
Mycobacterium tuberculosis
Medicine
Pharmacology (medical)
Mechanisms of Action: Physiological Effects
Pharmacology
chemistry.chemical_classification
biology
business.industry
bacterial infections and mycoses
biology.organism_classification
medicine.disease
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Cephalosporins
3. Good health
Infectious Diseases
Enzyme
chemistry
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
beta-Lactamase Inhibitors
business
Azabicyclo Compounds
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....a261b28156cc3d2315e916c49334b0ee
- Full Text :
- https://doi.org/10.1128/aac.05080-14