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AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics

AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics

Authors :
John J. Hablitz
Fu-Ming Zhou
Source :
Brain research. 780(1)
Publication Year :
1998

Abstract

The properties of spontaneous and miniature (m) AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) were studied in rat neocortical layer II/III fast spiking interneurons. Under optimal recording conditions, averaged mEPSCs had a 10-90% rise time of about 0.3 ms. The decay of averaged mEPSCs was double exponential with time constants of about 1 and 4 ms. Kinetics were observed to slow as series resistance increased. The amplitudes of mEPSCs were much smaller at +50 mV than at -50 mV indicating that the currents were inwardly rectifying. These results suggest that synaptic AMPA receptors on neocortical inhibitory interneurons have a deactivation time constant less than 1 ms which largely determines the decay of the synaptic currents. The receptors appear to lack GluR-2 subunits and may be Ca2+ permeable.

Details

ISSN :
00068993
Volume :
780
Issue :
1
Database :
OpenAIRE
Journal :
Brain research
Accession number :
edsair.doi.dedup.....a2567d522089274fcdd39d182c1ca511