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AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics
AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics
- Source :
- Brain research. 780(1)
- Publication Year :
- 1998
-
Abstract
- The properties of spontaneous and miniature (m) AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) were studied in rat neocortical layer II/III fast spiking interneurons. Under optimal recording conditions, averaged mEPSCs had a 10-90% rise time of about 0.3 ms. The decay of averaged mEPSCs was double exponential with time constants of about 1 and 4 ms. Kinetics were observed to slow as series resistance increased. The amplitudes of mEPSCs were much smaller at +50 mV than at -50 mV indicating that the currents were inwardly rectifying. These results suggest that synaptic AMPA receptors on neocortical inhibitory interneurons have a deactivation time constant less than 1 ms which largely determines the decay of the synaptic currents. The receptors appear to lack GluR-2 subunits and may be Ca2+ permeable.
- Subjects :
- Postsynaptic Current
Kinetics
Neocortex
AMPA receptor
In Vitro Techniques
Inhibitory postsynaptic potential
Rats, Sprague-Dawley
Interneurons
medicine
Animals
Receptors, AMPA
Receptor
Molecular Biology
Chemistry
General Neuroscience
Time constant
Excitatory Postsynaptic Potentials
Rats
medicine.anatomical_structure
nervous system
Excitatory postsynaptic potential
Biophysics
Neurology (clinical)
Neuroscience
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 780
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....a2567d522089274fcdd39d182c1ca511