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Personalizing health care: feasibility and future implications

Authors :
Lars L. Gustafsson
Alexander E. Finlayson
Marion Bennie
Kristina Garuoliene
Vera Vlahović-Palčevski
Magdalena Władysiuk
Christina Kvalheim
Laura McCullagh
Durhane Wong-Rieger
Catherine Sermet
Gisbert Selke
Elina Asola
Ulrich Schwabe
Stephen Campbell
Anna Bucsics
Raghib Ali
Christoph Baumgärtel
Saira Jan
Janelle M. Jones
Iñaki Gutiérrez-Ibarluzea
Corrine Zara
D Tomek
Luka Voncina
Eva Zebedin-Brandl
Steven Simoens
Katharine Harris
Miguel Gomes
Harald Herholz
Rickard E. Malmström
Sven-Ake Loov
Parneet K Cheema
Alessandra Ferrario
Fredrik Nilsson
Eduardo Diogene
Krystyna Hviding
Brian Godman
Kamila Malinowska
Iain Bishop
Ken Paterson
Jurij Fürst
Andrew Martin
Menno van Woerkom
Marija Kalaba
Alan Haycox
Ott Laius
Source :
BMC Medicine, Volume 11, Issue 1, BMC medicine
Publication Year :
2013

Abstract

Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer’s perspective to provide future guidance. Multiple findings including general considerations ; influence of pharmacogenomics on response and toxicity of drug therapies ; value of biomarker tests ; limitations and costs of tests ; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients

Details

Language :
English
ISSN :
17417015
Database :
OpenAIRE
Journal :
BMC Medicine, Volume 11, Issue 1, BMC medicine
Accession number :
edsair.doi.dedup.....a2566d7c1f87170c9a254f13950f8a5d
Full Text :
https://doi.org/10.1186/1741-7015-11-179