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Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study
- Source :
- Clinical Microbiology and Infection
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Summary Objectives The coronavirus disease 2019 (COVID-19) pandemic situation in Germany is unique among large European countries in that incidence and case fatality rate are distinctly lower. We describe the clinical course and examine factors associated with outcomes among patients hospitalized with COVID-19 in Germany. Methods In this retrospective cohort study we included patients with COVID-19 admitted to a national network of German hospitals between February 12, and June 12, 2020. We examined demographic characteristics, comorbidities and clinical outcomes. Results We included 1904 patients with a median age of 73 years, and 48.5% (924/1904) were female. The mortality rate was 17% (317/1835; 95% confidence interval [CI] 16-19), the rate of admission to the intensive care unit (ICU) 21% (399/1860; 95% CI 20–23), and the rate of invasive mechanical ventilation 14% (250/1850: 95% CI 12–15). The most prominent risk factors for death were male sex (hazard ratio [HR] 1.45; 95% CI 1.2-1.8), preexisting lung disease (HR 1.61; 95% CI 1.20-2.16), and increased patient age (HR 4.1 [95% CI 2.6–6.6] for age >79 years versus
- Subjects :
- 0301 basic medicine
Male
Microbiology (medical)
medicine.medical_specialty
Critical Care
030106 microbiology
Comorbidity
Article
law.invention
03 medical and health sciences
0302 clinical medicine
Sex Factors
law
Risk Factors
Internal medicine
Germany
Case fatality rate
medicine
Humans
030212 general & internal medicine
Hospital Mortality
Pandemics
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Incidence (epidemiology)
Mortality rate
Incidence
Hazard ratio
Age Factors
COVID-19
Retrospective cohort study
General Medicine
Middle Aged
Intensive care unit
Respiration, Artificial
Confidence interval
Hospitalization
Intensive Care Units
Infectious Diseases
Female
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 1198743X
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection
- Accession number :
- edsair.doi.dedup.....a2542594a4ad5f12afe78b146899dab5
- Full Text :
- https://doi.org/10.1016/j.cmi.2020.08.011