Back to Search
Start Over
Evaluation of solubility enhancement, antioxidant activity, and cytotoxicity studies of kynurenic acid loaded cyclodextrin nanosponge
- Publication Year :
- 2019
-
Abstract
- Kynurenic acid demonstrates antioxidant, neuroprotective and free radical scavenging properties. However, low aqueous solubility of kynurenic acid limits its therapeutic activity. In the present study, cyclodextrin nanosponges were used to improve the solubility and therapeutic activity of kynurenic acid. The formation of kynurenic acid loaded nanosponge was confirmed by different characterization techniques. The solubility of kynurenic acid was significantly increased with nanosponge (111.1 μg/ml) compared to free kynurenic acid (16.4 μg/ml) and β-cyclodextrin (28.6 μg/ml). High drug loading (19.06%) and encapsulation efficiency (95.31%) were achieved with NS. The particle size and zeta potential of kynurenic acid loaded nanosponge was around 255.8 nm and −23 mV respectively. Moreover, higher solubilization of kynurenic acid loaded nanosponge produced better antioxidant activity compared to free kynurenic acid. The kynurenic acid loaded nanosponge and blank nanosponge were found nontoxic in the cytotoxicity assay. Thus, these studies demonstrated that nanosponges can be used as a carrier for the delivery of kynurenic acid.
- Subjects :
- Nanosponges
Antioxidant
Polymers and Plastics
Cell Survival
medicine.medical_treatment
02 engineering and technology
Kynurenic Acid
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Kynurenic acid
Antioxidant activity
Cell Line, Tumor
Drug-delivery
Kynurenic acidd
Solubility enhancement
β-cyclodextrin
Materials Chemistry
Zeta potential
medicine
Humans
Solubility
Cytotoxicity
chemistry.chemical_classification
Cyclodextrins
Drug Carriers
Cyclodextrin
Organic Chemistry
Free Radical Scavengers
021001 nanoscience & nanotechnology
Nanostructures
0104 chemical sciences
chemistry
Drug delivery
0210 nano-technology
Nuclear chemistry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a24ec4edc9664d2545c66f27495a812f