Back to Search
Start Over
G119S ace-1 mutation conferring insecticide resistance detected in the Culex pipiens complex in Morocco
- Source :
- Pest Management Science, Pest Management Science, Wiley, 2019, 75 (1), pp.286-291. ⟨10.1002/ps.5114⟩
- Publication Year :
- 2018
-
Abstract
- International audience; Background: Arboviruses are controlled through insecticide control of their mosquito vector. However, inconsiderate use of insecticides often results in the selection of resistance in treated populations, so that monitoring is required to optimize their usage. Here, Culex pipiens (West Nile and Rift Valley Fever virus vector) specimens were collected from four Moroccan cities. Levels of susceptibility to the organophosphate (OP) insecticide malathion were assessed using World Health Organization (WHO)-recommended bioassays. Individual mosquitoes were tested for the presence of the G119S mutation in the ace-1 gene, the main OP-target resistance mutation.Results: Bioassays showed that mosquitoes from Mohammedia were significantly more resistant to malathion than those from Marrakech. Analyzing the ace-1 genotypes in dead and surviving individuals suggested that other resistance mechanisms may be present in Mohammedia. The ace-1 resistance allele frequencies were relatively moderate (< 0.4). Their analyses in three Moroccan cities (Tangier, Casablanca and Marrakech) however showed disparities between two coexisting Cx. pipiens forms and revealed that the G119S mutation tends to be more frequent in urban than in rural collection sites.Conclusion: These findings provide a reference assessment of OP resistance in Morocco and should help the health authorities to develop informed and sustainable vector control programs. © 2018 Society of Chemical Industry.
- Subjects :
- 0301 basic medicine
Veterinary medicine
Insecticides
MESH: Mutation
Culex
030231 tropical medicine
MESH: Culex
G119S ace-1
Insecticide Resistance
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Gene Frequency
Culex pipiens
Genotype
MESH: Insect Proteins
MESH: Cities
MESH: Gene Frequency
MESH: Insecticide Resistance
Animals
MESH: Animals
Cities
Allele frequency
biology
Organophosphate
MESH: Malathion
General Medicine
MESH: Acetylcholinesterase
biology.organism_classification
Resistance mutation
3. Good health
MESH: Insecticides
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
Morocco
030104 developmental biology
chemistry
Insect Science
Vector (epidemiology)
MESH: Morocco
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Mutation
Acetylcholinesterase
Malathion
Insect Proteins
Agronomy and Crop Science
Subjects
Details
- ISSN :
- 15264998 and 1526498X
- Volume :
- 75
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pest management science
- Accession number :
- edsair.doi.dedup.....a23aa764d5064f15f3c5e3754fdf96e7