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Preoperative vs Postoperative Eradication of Helicobacter pylori in 150 Patients with Gastric Cancer: A Randomized Controlled Trial
- Source :
- Journal of the American College of Surgeons. 221(2)
- Publication Year :
- 2015
-
Abstract
- Background The Maastricht, Asia-Pacific consensus guidelines strongly recommend eradication of Helicobacter pylori in patients who have a history of gastric cancer. This open-label, single-center, randomized controlled trial was conducted to investigate the appropriate timing of eradication for patients undergoing gastrectomy. Study Design One hundred and fifty patients scheduled to undergo gastrectomy were allocated to either a preoperative or a postoperative group. The eradication regimen was a common triple therapy: lansoprazole, amoxicillin, and clarithromycin. Patients in the preoperative group were treated with the regimen, followed by surgery, and patients in the postoperative group were treated after postoperative day 8. The primary end point was the proportion of patients achieving successful eradication in the remnant stomach. The definition of successful eradication was negativity in both the C13 urea breath test and for the antigen in feces at 6 months after surgery. Results Eight patients were excluded, and the remaining one hundred and forty-two, 70 in the preoperative group and 72 in the postoperative group, were included on an intention to treat basis. The procedures used were gastrectomy with Billroth I, Roux-en-Y, and pylorus-preserving gastrectomy in 18, 70, and 57 patients, respectively. The proportion of patients showing successful eradication hardly differed between the 2 groups, 68.6% vs 69.4% (p = 1.000) in the pre- and postoperative groups, respectively. Subgroup analysis also demonstrated no significant difference among the reconstruction methods used. Conclusions Preoperative H pylori eradication therapy for gastric cancer patients scheduled for gastrectomy is not necessary, regardless of the planned reconstruction procedure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Urea breath test
medicine.medical_treatment
macromolecular substances
Adenocarcinoma
Gastroenterology
Drug Administration Schedule
law.invention
Helicobacter Infections
Randomized controlled trial
law
Gastrectomy
Stomach Neoplasms
Clarithromycin
Internal medicine
Preoperative Care
medicine
Humans
Billroth I
Lansoprazole
Aged
Aged, 80 and over
Postoperative Care
Intention-to-treat analysis
medicine.diagnostic_test
biology
Helicobacter pylori
business.industry
Amoxicillin
Proton Pump Inhibitors
Middle Aged
biology.organism_classification
Surgery
Anti-Bacterial Agents
Regimen
Treatment Outcome
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 18791190
- Volume :
- 221
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Surgeons
- Accession number :
- edsair.doi.dedup.....a23767ff46489a23f127fcbf6bb05a0f