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Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications
- Source :
- Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 166-179 (2021), Molecular Therapy Oncolytics
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Immunotherapy has been well regarded as one of the safer and antigen-specific anti-cancer treatments compared to first-generation chemotherapy. Since Coley’s discovery, researchers focused on engineering novel antibody-based therapies. Including artificial and modified antibodies, such as antibody fragments, antibody-drug conjugates, and synthetic mimetics, the variety of immunotherapy has been rapidly expanding in the last few decades. Genetic and chemical modifications to monoclonal antibody have been brought into academia, in vivo trials, and clinical applications. Here, we have looked around antibodies overall. First, we elucidate the antibody structure and its cytotoxicity mechanisms. Second, types of therapeutic antibodies are presented. Additionally, there is a summarized list of US Food and Drug Administration (FDA)-approved therapeutic antibodies and recent clinical trials. This review provides a comprehensive overview of both the general function of therapeutic antibodies and a few main variations in development, including recent advent with the proposed mechanism of actions, and we introduce types of therapeutic antibodies, clinical trials, and approved commercial immunotherapeutic drugs.<br />Graphical abstract<br />We provide a general overview of both clinical and experimental models of novel, modified antibodies along with their test case results. Overall, antibody extensions are coming close to becoming equal or more therapeutically favorable than traditional ones, especially in terms of bio-efficacy and toxicity.
- Subjects :
- Cancer Research
medicine.drug_class
medicine.medical_treatment
T lymphocytes
Review
Bioinformatics
Monoclonal antibody
Antibody fragments
Food and drug administration
Medicine
Pharmacology (medical)
RC254-282
biology
business.industry
Mechanism (biology)
General function
apoptosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunotherapy
immune-related adverse effects
Clinical trial
Oncology
therapeutic antibody
biology.protein
Molecular Medicine
cytotoxicity
immunotherapy
Antibody
business
anti-cancer therapy
Subjects
Details
- Language :
- English
- ISSN :
- 23727705
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecular Therapy: Oncolytics
- Accession number :
- edsair.doi.dedup.....a232790a25bb53b5085be5c156b0a013