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Prevalence of sexual dimorphism in mammalian phenotypic traits
- Source :
- Nature Communications, Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩, Nature communications, vol 8, iss 1, Nat. Commun. 8:15475 (2017), Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.<br />Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.
- Subjects :
- 0301 basic medicine
Genotype
Science
Mutant
General Physics and Astronomy
[SDV.GEN] Life Sciences [q-bio]/Genetics
Quantitative trait locus
Biology
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Mice
Quantitative Trait
Quantitative Trait, Heritable
Genetics
Animals
Modifier
Gene
Heritable
Mammals
Sex Characteristics
[SDV.GEN]Life Sciences [q-bio]/Genetics
Multidisciplinary
Genes, Modifier
Body Weight
General Chemistry
Phenotypic trait
Phenotype
Sexual dimorphism
030104 developmental biology
Genes
Evolutionary biology
Female
International Mouse Phenotyping Consortium
Sex characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩, Nature communications, vol 8, iss 1, Nat. Commun. 8:15475 (2017), Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
- Accession number :
- edsair.doi.dedup.....a22ff32917f16b5f536bab3a8bab6e17
- Full Text :
- https://doi.org/10.1038/ncomms15475⟩