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Acute application of Centella asiatica extract enhanced AMPAR-mediated postsynaptic currents in rat entorhinal cortex
- Source :
- Journal of Integrative Neuroscience, Vol 19, Iss 2, Pp 217-227 (2020)
- Publication Year :
- 2020
- Publisher :
- IMR Press, 2020.
-
Abstract
- Centella asiatica is notable for its wide range of biological activities beneficial to human health, particularly its cognitive enhancement and neuroprotective effects. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are ionotropic glutamate receptors mediating fast excitatory neurotransmission essential in long-term potentiation widely thought to be the cellular mechanism of learning and memory. The method of whole-cell patch-clamp was used to study the effect of the acute application of Centella asiatica extract on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated spontaneous excitatory postsynaptic currents in the entorhinal cortex of rat brain slices. The respective low dose of test compounds significantly increased the amplitude of spontaneous excitatory postsynaptic currents while having no significant effects on the frequency. The findings suggested that Centella asiatica extract increased the response of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the postsynaptic level, revealing the potential role of Centella asiatica in modulating the glutamatergic responses in the entorhinal cortex of rat brain slices to produce cognitive enhancement effects.
- Subjects :
- Centella
biology
Postsynaptic Current
Chemistry
General Neuroscience
05 social sciences
Glutamate receptor
General Medicine
Pharmacology
Neurotransmission
biology.organism_classification
Entorhinal cortex
050105 experimental psychology
lcsh:RC321-571
03 medical and health sciences
Glutamatergic
0302 clinical medicine
Postsynaptic potential
centella asiatica|asiatic acid|asiaticoside|whole-cell patch-clamp|ampar|entorhinal cortex
Excitatory postsynaptic potential
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1757448X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Integrative Neuroscience
- Accession number :
- edsair.doi.dedup.....a21d3a2f4557e969e6297a4a22194120