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Serum hepcidin levels are associated with obesity but not liver disease
- Source :
- Obesity (Silver Spring, Md.)
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Objective Hepcidin is regulated by anemia and inflammation. It is primarily expressed in the liver but studies have reported its expression in adipose tissue. The relationship between BMI and serum hepcidin and the relationship between liver histology and serum hepcidin in the morbidly obese was investigated. Methods Serum and liver tissue from patients undergoing bariatric surgery (bariatric cohort, n = 105) and serum from healthy blood donors (n = 60) were used to conduct this study. Serum hepcidin was measured using sandwich ELISA, highly specific for hepcidin-25. Serum ferritin, IL-6, IL-1β and liver function biochemistries were also measured. Results After controlling for covariates, BMI ≥ 35 kg/m2 was significantly associated with higher serum hepcidin level compared to individuals with lower BMI groups (17.7 ± 11.5 vs. 3.3 ± 4.7 ng/ml, P = 0.002). The presence of NAFLD was not associated with higher serum levels of hepcidin (multivariate P = 0.37). There was no association between serum hepcidin levels and liver histology (presence of steatohepatitis, advanced fibrosis, or NAFLD activity score) in the bariatric cohort. Conclusions Obesity, but not the presence of NAFLD was associated with serum hepcidin levels. There was no association between serum hepcidin and liver histology in the morbidly obese undergoing bariatric surgery.
- Subjects :
- Male
obesity
Endocrinology, Diabetes and Metabolism
Interleukin-1beta
Bariatric Surgery
Medicine (miscellaneous)
Adipose tissue
Body Mass Index
Cohort Studies
Liver disease
0302 clinical medicine
Endocrinology
hemic and lymphatic diseases
Nutrition and Dietetics
biology
Liver Diseases
Fatty liver
Middle Aged
Obesity, Morbid
3. Good health
Serum hepcidin
Liver
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Adult
inorganic chemicals
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Anemia
digestive system
Article
03 medical and health sciences
Hepcidins
Hepcidin
Internal medicine
medicine
Humans
Interleukin-6
business.industry
ferritin
non-alcoholic fatty liver disease
nutritional and metabolic diseases
medicine.disease
Fatty Liver
Ferritins
Multivariate Analysis
Linear Models
biology.protein
Liver function
Steatohepatitis
business
Body mass index
Subjects
Details
- ISSN :
- 1930739X and 19307381
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi.dedup.....a219b4001d27673b7023445b88c65aaa