CMR Tissue Characterization in Patients with HFmrEF

The characteristics and optimal management of heart failure with a moderately reduced ejection fraction (HFmrEF, LV-EF 40&ndash
50%) are still unclear. Advanced cardiac MRI offers information about function, fibrosis and inflammation of the myocardium, and might help to characterize HFmrEF in terms of adverse cardiac remodeling. We, therefore, examined 17 patients with HFpEF, 18 with HFmrEF, 17 with HFrEF and 17 healthy, age-matched controls with cardiac MRI (Phillips 1.5 T). T1 and T2 relaxation time mapping was performed and the extracellular volume (ECV) was calculated. Global circumferential (GCS) and longitudinal strain (GLS) were derived from cine images. GLS (&minus
15.7 &plusmn
2.1) and GCS (&minus
19.9 &plusmn
4.1) were moderately reduced in HFmrEF, resembling systolic dysfunction. Native T1 relaxation times were elevated in HFmrEF (1027 &plusmn
40 ms) and HFrEF (1033 &plusmn
54 ms) compared to healthy controls (972 &plusmn
31 ms) and HFpEF (985 &plusmn
32 ms). T2 relaxation times were elevated in HFmrEF (55.4 &plusmn
3.4 ms) and HFrEF (56.0 &plusmn
6.0 ms) compared to healthy controls (50.6 &plusmn
2.1 ms). Differences in ECV did not reach statistical significance. HFmrEF differs from healthy controls and shares similarities with HFrEF in cardiac MRI parameters of fibrosis and inflammation.