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IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms
- Source :
- Wang, J, Lindholt, J S, Sukhova, G K, Shi, M A, Xia, M, Chen, H, Xiang, M, He, A, Wang, Y, Xiong, N, Libby, P, Wang, J-A & Shi, G-P 2014, ' IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms ', E M B O Molecular Medicine (Online), vol. 6, no. 7, pp. 952-969 . https://doi.org/10.15252/emmm.201303811, EMBO Molecular Medicine
- Publication Year :
- 2014
-
Abstract
- Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates that CD4+ T cells express IgE receptor FcεR1, at much higher levels than do CD8+ T cells. IgE induces CD4+ T-cell production of IL6 and IFN-γ, but reduces their production of IL10. FcεR1 deficiency (Fcer1a-/-) protects apolipoprotein E-deficient (Apoe-/-) mice from angiotensin-II infusion-induced AAAs and reduces plasma IL6 levels. Adoptive transfer of CD4+ T cells (but not CD8+ T cells), MCs, and macrophages from Apoe-/- mice, but not those from Apoe-/- Fcer1a-/- mice, increases AAA size and plasma IL6 in Apoe-/- Fcer1a-/- recipient mice. Biweekly intravenous administration of an anti-IgE monoclonal antibody ablated plasma IgE and reduced AAAs in Apoe-/- mice. Patients with AAAs had significantly higher plasma IgE levels than those without AAAs. This study establishes an important role of IgE in AAA pathogenesis by activating CD4+ T cells, MCs, and macrophages and supports consideration of neutralizing plasma IgE in the therapeutics of human AAAs.
- Subjects :
- Apolipoprotein E
CD4-Positive T-Lymphocytes
Male
Adoptive cell transfer
Macrophage
T cells
macrophage
macromolecular substances
030204 cardiovascular system & hematology
Biology
CD8-Positive T-Lymphocytes
Immunoglobulin E
Mast cell
03 medical and health sciences
Mice
0302 clinical medicine
abdominal aortic aneurysm
medicine
Animals
Humans
Mast Cells
cardiovascular diseases
Research Articles
030304 developmental biology
0303 health sciences
Receptors, IgE
FCER1
Macrophages
FCER1A
Adoptive Transfer
3. Good health
Up-Regulation
Mice, Inbred C57BL
Interleukin 10
medicine.anatomical_structure
Immunology
biology.protein
cardiovascular system
Molecular Medicine
Abdominal aortic aneurysm
Female
IgE
mast cell
CD8
Gene Deletion
Aortic Aneurysm, Abdominal
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Wang, J, Lindholt, J S, Sukhova, G K, Shi, M A, Xia, M, Chen, H, Xiang, M, He, A, Wang, Y, Xiong, N, Libby, P, Wang, J-A & Shi, G-P 2014, ' IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms ', E M B O Molecular Medicine (Online), vol. 6, no. 7, pp. 952-969 . https://doi.org/10.15252/emmm.201303811, EMBO Molecular Medicine
- Accession number :
- edsair.doi.dedup.....a216cd106a657bb1700e23a2cc02bbd5
- Full Text :
- https://doi.org/10.15252/emmm.201303811