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Linc00473 as an immediate early gene under the control of the egr1 transcription factor
- Source :
- Non-Coding RNA, Volume 6, Issue 4, Non-Coding RNA, Vol 6, Iss 46, p 46 (2020)
- Publication Year :
- 2020
-
Abstract
- Immediate early genes play an essential role in cellular responses to different stimuli. Many of them are transcription factors that regulate the secondary response gene expression. Non-coding RNAs may also be involved in this regulatory cascade. In fact, they are emerging as key actors of gene expression regulation, and evidence suggests that their dysregulation may underly pathological states. We previously took a snapshot of both coding and long non-coding RNAs differentially expressed in neuronal cells after brain-derived neurotrophic factor stimulation. Among these, the transcription factor EGR1 (a well-known immediate early gene) and LINC00473 (a primate-specific long non-coding RNA) that has emerged as an interesting RNA candidate involved in neuronal function and in cancer. In this work, we demonstrated that LINC00473 gene expression kinetics resembled that of immediate early genes in SH-SY5Y and HEK293T cells under different cell stimulation conditions. Moreover, we showed that the expression of LINC00473 is under the control of the transcription factor EGR1, providing evidence for an interesting functional relationship in neuron function.
- Subjects :
- 0301 basic medicine
lcsh:QH426-470
EGR1
Biology
immediate-early genes
Biochemistry
Article
03 medical and health sciences
0302 clinical medicine
Gene expression
Genetics
LINC00473
Molecular Biology
Gene
Transcription factor
Regulation of gene expression
Immediate-early gene
HEK 293 cells
C6orf176
RNA
Cell biology
lcsh:Genetics
030104 developmental biology
BDNF
Long non-coding RNAs
Immediate early gene
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Non-Coding RNA, Volume 6, Issue 4, Non-Coding RNA, Vol 6, Iss 46, p 46 (2020)
- Accession number :
- edsair.doi.dedup.....a216c976ab7af836cd602e57c90d8bb7