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Use of external ventriculostomy and intrathecal anti-fungal treatment in cerebral mucormycotic abscess
- Source :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 21(10)
- Publication Year :
- 2013
-
Abstract
- Mucormycosis is an invasive fungal infection associated with a high mortality. Cerebral mucor abscesses can result secondary to rhinocerebral or hematogenous spread. Amphotericin B, posaconazole, and aggressive surgical resection are the hallmarks of treatment. While amphotericin is typically administered intravenously, less is known about the use of intrathecal amphotericin B. We describe a 42-year-old man who developed a cerebellar mucor abscess after undergoing hematopoietic stem cell transplant for the treatment of myelodysplastic syndrome. In the post-operative period he was admitted to the neurocritical care unit and received liposomal amphotericin B intravenously and through an external ventricular drain. This patient demonstrates that utilization of an external ventricular drain for intrathecal antifungal therapy in the post-operative period may warrant further study in patients with difficult to treat intracranial fungal abscesses.
- Subjects :
- Ventriculostomy
Adult
Male
medicine.medical_specialty
Posaconazole
Antifungal Agents
medicine.medical_treatment
Brain Abscess
Physiology (medical)
Amphotericin B
medicine
Humans
Mucormycosis
Abscess
Brain abscess
Injections, Spinal
business.industry
Hematopoietic Stem Cell Transplantation
Neurointensive care
Brain
General Medicine
bacterial infections and mycoses
medicine.disease
Surgery
Neurology
Anesthesia
Myelodysplastic Syndromes
Neurology (clinical)
business
Magnetic Resonance Angiography
External ventricular drain
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 15322653
- Volume :
- 21
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
- Accession number :
- edsair.doi.dedup.....a20dcf8f6d77cd94ff885c4d739695cd