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Glycosylation at the fetomaternal interface in hemomonochorial placentae from five widely separated species of mammal: is there evidence for convergent evolution?
- Source :
- Jones, C J P, Carter, A M, Aplin, J D & Enders, A C 2007, ' Glycosylation at the fetomaternal interface in hemomonochorial placentae from five widely separated species of mammal : is there evidence for convergent evolution? ', Cells, Tissues, Organs, vol. 185, no. 4, pp. 269-284 . https://doi.org/10.1159/000102175
- Publication Year :
- 2007
-
Abstract
- Hemomonochorial placentation occurs in diverse species. We have examined placental glycosylation in five widely separated mammals with this type of placentation – lesser hedgehog tenrec (Echinops telfairi), spotted hyena (Crocuta crocuta), nine-banded armadillo (Dasypus novemcinctus), human (Homo sapiens) and guinea pig (Cavia porcellus) – in order to assess whether evolutionary convergence to the hemomonochorial state is accompanied by a similar convergence of glycan expression. Placentae from 2 E. telfairi, 3 C. crocuta, 1 D. novemcinctus, 4 womenand 1 C. porcellus were fixed and processed into epoxy resin. Binding of twenty-three lectins was assessed using a semiquantitative ranking system. The trophoblast apical/microvillous membrane of all five species showed marked similarities in glycosylation. In the N-linked series, there were abundant bi/tri-antennary complex chains, while the non-bisected variants were much scarcer. All species had plentiful N-acetyl lactosamine sequences; at chain termini, binding to Galβ1,4GlcNAc and Galβ1,3GalNAc sequences was greatly enhanced after neuraminidase treatment. In all species, terminal NeuNAcα2,3 residues were detected. The tenrec had unusually abundant terminal N-acetyl galactosamine. The basal plasma membrane/basal lamina showed glycosylation patterns distinct from the microvillous membrane in each case, indicating chemical diversity of the two opposite faces of trophoblast. Similar classes of glycan at the hemochorial interface suggest conservation of function. The observed lectin binding patterns suggest broad similarities of glycosylation that may have arisen by convergent evolution.
- Subjects :
- Glycan
Armadillos
Histology
Glycosylation
Evolution
Placenta
Guinea Pigs
Crocuta crocuta
Tenrec
chemistry.chemical_compound
Species Specificity
Polysaccharides
Pregnancy
biology.animal
Lectins
Animals
Humans
Maternal-Fetal Exchange
Echinops telfairi
Mammals
biology
Microvilli
Histocytochemistry
Eulipotyphla
Insectivora
biology.organism_classification
Biological Evolution
Basal plasma membrane
Trophoblasts
Dasypus novemcinctus
chemistry
Evolutionary biology
Armadillo
Immunology
biology.protein
Female
Hyaenidae
Anatomy
Subjects
Details
- ISSN :
- 14226421
- Volume :
- 185
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cells, tissues, organs
- Accession number :
- edsair.doi.dedup.....a20b2a6c98c94c5feb881410def2f4f4