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Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma
Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma
- Source :
- Anticancer Research. 37:1387-1392
- Publication Year :
- 2017
- Publisher :
- Anticancer Research USA Inc., 2017.
-
Abstract
- BACKGROUND In the literature, there exist conflicting data on the value of fibulin-3 (FBLN3) for the diagnosis of pleural effusion (PE) in malignant pleural mesothelioma (MPM). Therefore we compared the diagnostic performance of FBLN3 against that of soluble mesothelin-related peptide (SMRP) in a cohort of Italian patients. MATERIALS AND METHODS FBLN3 and SMRP were detected in PE from 33 patients with MPM, 64 with pleural benign lesions and 23 with non-MPM pleural metastases using a commercial enzyme-linked-immunosorbent(ELISA)-assay kit according to manufacturers' instructions. RESULTS Levels of FBLN3 were similar in PE from MPM and PE from other pathologies (geometric mean=68.1 vs. 66.2 ng/ml; p=0.872) in contrast to SMRP levels, which were significantly higher in PE from MPM (geometric mean=14.6 vs. 3.2 nM; p
- Subjects :
- Male
Mesothelioma
0301 basic medicine
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Pleural effusion
Pleural Neoplasms
Enzyme-Linked Immunosorbent Assay
Gastroenterology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
Humans
Medicine
In patient
Mesothelin
Aged
Aged, 80 and over
Extracellular Matrix Proteins
Receiver operating characteristic analysis
biology
business.industry
Mesothelioma, Malignant
Area under the curve
General Medicine
Middle Aged
medicine.disease
Pleural Effusion, Malignant
Fibulin
Gene Expression Regulation, Neoplastic
030104 developmental biology
Italy
ROC Curve
Oncology
030220 oncology & carcinogenesis
biology.protein
Biomarker (medicine)
Female
Multidrug Resistance-Associated Proteins
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....a1ffeb4b16ebc6a392d6c9ec82fdcd0b
- Full Text :
- https://doi.org/10.21873/anticanres.11460