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Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma

Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma

Authors :
Paolo Dessanti
Silvio Roncella
Valentina Pinelli
Enrico Battolla
Anna Morabito
Franco Fedeli
Maria Cristiana Franceschini
Pier Aldo Canessa
Maria Pia Pistillo
Paola Ferro
Vincenzo Fontana
Source :
Anticancer Research. 37:1387-1392
Publication Year :
2017
Publisher :
Anticancer Research USA Inc., 2017.

Abstract

BACKGROUND In the literature, there exist conflicting data on the value of fibulin-3 (FBLN3) for the diagnosis of pleural effusion (PE) in malignant pleural mesothelioma (MPM). Therefore we compared the diagnostic performance of FBLN3 against that of soluble mesothelin-related peptide (SMRP) in a cohort of Italian patients. MATERIALS AND METHODS FBLN3 and SMRP were detected in PE from 33 patients with MPM, 64 with pleural benign lesions and 23 with non-MPM pleural metastases using a commercial enzyme-linked-immunosorbent(ELISA)-assay kit according to manufacturers' instructions. RESULTS Levels of FBLN3 were similar in PE from MPM and PE from other pathologies (geometric mean=68.1 vs. 66.2 ng/ml; p=0.872) in contrast to SMRP levels, which were significantly higher in PE from MPM (geometric mean=14.6 vs. 3.2 nM; p

Details

ISSN :
17917530 and 02507005
Volume :
37
Database :
OpenAIRE
Journal :
Anticancer Research
Accession number :
edsair.doi.dedup.....a1ffeb4b16ebc6a392d6c9ec82fdcd0b
Full Text :
https://doi.org/10.21873/anticanres.11460