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The Association Between the Duration, Treatment, Control of Hypertension and Lifestyle Risk Factors in Middle-Aged and Elderly Patients with Mild Cognitive Impairment: A Case-Control Study
- Source :
- Neuropsychiatric Disease and Treatment. 18:585-595
- Publication Year :
- 2022
- Publisher :
- Informa UK Limited, 2022.
-
Abstract
- Xiwu Yan,1â 3 Ting Meng,2,3 Huaijun Liu,2 Jinfeng Liu,3 Juan Du,1 Cheng Chang3 1Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, Peopleâs Republic of China; 2Key Laboratory of Cognitive Impairment Research, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, Peopleâs Republic of China; 3Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, Peopleâs Republic of ChinaCorrespondence: Cheng Chang; Xiwu Yan, Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210000, Peopleâs Republic of China, Tel +86 13851821996 ; +86 18013930106, Email yxwssg@126.com; chch1967@163.comBackground: Epidemiological studies suggest that the incidence of hypertension in China is causally related to cognitive impairment. However, there is a dearth of information available regarding important factors for the association, including disease duration, therapeutic options, and risk factors associated with mild cognitive impairment (MCI) in patients with hypertension.Methods: We selected a diverse cohort of 572 patients with hypertension and assessed cognitive function using MoCA. Potential risk factors were investigated by a structured questionnaire. Risk factors associated with the hypertension-induced MCI occurring conversion of were analyzed using multifactorial regression analysis.Results: MCI was observed in 256 of 572 individuals, which increased with age (OR=1.15, 95% CI 1.10â 1.20), but was decreased with high education status (OR=0.47, 95% CI 0.32â 0.71). Risk factors independently associated with MCI were diabetes (OR=2.40, 95% CI 1.53â 3.76), hyperlipidemia (OR=1.49, 95%=1.01â 2.16), high salt diet (OR=2.27, 95% CI 1.34â 3.84), and physical activity:> 2h/week (OR=0.65, 95%0.44â 0.94). However, controlling blood pressure to ânormalâ target values helped decrease the incidence of MCI (OR=0.44, 95% CI 0.30â 0.65): this was not age dependent.Conclusion: Our results suggest that it is necessary to promote the education of the middle-aged and elderly Chinese population to correctly and effectively use anti-hypertensives to control hypertension to a normal range to prevent cognitive.Keywords: hypertension, mild cognitive impairment, control, risk factors
- Subjects :
- Neuropsychiatric Disease and Treatment
Subjects
Details
- ISSN :
- 11782021
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Neuropsychiatric Disease and Treatment
- Accession number :
- edsair.doi.dedup.....a1f675f18b4f553cd13cb0e63ea1a5b0
- Full Text :
- https://doi.org/10.2147/ndt.s353164