Back to Search
Start Over
Selective elimination of malignant stem cells using photosensitizers followed by light treatment
- Source :
- STEM CELLS. 13:336-343
- Publication Year :
- 1995
- Publisher :
- Oxford University Press (OUP), 1995.
-
Abstract
- The pros and cons of purging of either bone marrow or peripheral blood stem cell preparations for autologous transplantation for cancer has been debated strongly over the past decade. Recent data implicating the role of minimal residual disease in autografted marrow in cancer relapse have renewed interest in this question. There is a considerable body of literature supporting the possibility that photosensitizer molecules in combination with light might provide a therapeutic window permitting selective elimination of malignant stem cells while sparing those of normal lineage. Molecules of this class are known to be taken up more actively by most malignant cells, and intracellular concentrations are critical in their cytotoxic effect when they are activated by light at an appropriate wavelength. The present paper reviews the observations made over the past decade on a variety of photosensitizers and their effects on hemopoietic progenitors.
- Subjects :
- Indoles
Porphyrins
Light
Pyrimidinones
Biology
Neoplasms
Organometallic Compounds
medicine
Humans
Cytotoxic T cell
Autologous transplantation
Hematoporphyrin Derivative
Photosensitizer
Bone Marrow Transplantation
Photosensitizing Agents
Bone Marrow Purging
Hematopoietic Stem Cell Transplantation
Cancer
Cell Biology
Hematopoietic Stem Cells
medicine.disease
Minimal residual disease
Leukemia
medicine.anatomical_structure
Immunology
Neoplastic Stem Cells
Cancer research
Molecular Medicine
Bone marrow
Stem cell
Developmental Biology
Subjects
Details
- ISSN :
- 15494918 and 10665099
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- STEM CELLS
- Accession number :
- edsair.doi.dedup.....a1f4b9d42913de7d073cf40c573ab94d