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A New Aggressive Treatment Approach to High-Grade Endometrial Cancer of Possible Benefit to Patients with Stage I Uterine Papillary Cancer
- Source :
- Gynecologic Oncology. 48:32-37
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Between January 1, 1988 and December 31, 1990, a new high-intensity treatment was delivered to 10 patients with clinical stage I uterine papillary serous carcinoma (UPSC) and 21 patients with clinical stage I, FIGO grade 3 endometrial adenocarcinoma. The treatment consisted of a radical hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node sampling, adjuvant external pelvic radiation, and four courses of cis -platinum/epirubicin. The clinical outcome was compared to that of a historical control group treated before 1998 with surgery and radiation. None of the high-intensity treated UPSC patients died or relapsed during a median observation time of 32 months. There was a significantly better survival in the high-intensity treated UPSC group compared to the controls. The UPSC patients diagnosed after January 1, 1988 showed a trend toward better survival compared to those diagnosed before this date, whether they had received high-intensity treatment or not. No significant difference in survival was observed in the non-UPSC group subjected or not to the high-intensity treatment.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Uterus
Adenocarcinoma
Endometrium
Clinical Protocols
medicine
Humans
Radical Hysterectomy
Aged
Neoplasm Staging
Aged, 80 and over
Chemotherapy
business.industry
Endometrial cancer
Obstetrics and Gynecology
Cancer
Middle Aged
medicine.disease
Combined Modality Therapy
Survival Analysis
Carcinoma, Papillary
Endometrial Neoplasms
Surgery
Radiation therapy
Treatment Outcome
medicine.anatomical_structure
Oncology
Female
business
Epirubicin
medicine.drug
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....a1d9ed00e46982fada84c3f95704f4df