Back to Search
Start Over
Ureteral Involvement and Diabetes Increase the Risk of Subsequent Bladder Recurrence after Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
- Source :
- BioMed Research International, BioMed Research International, Vol 2015 (2015), Urological Science, Vol 26, Iss 2, Pp S14-S15 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objectives.To investigate the prognostic factors for bladder recurrence after radical nephroureterectomy (RNU) in patients with upper urinary tract urothelial carcinoma (UUT-UC).Methods.From 1994 to 2012, 695 patients with UUT-UC treated with RNU were enrolled in National Taiwan University Medical Center. Among them, 532 patients with no prior bladder UC history were recruited for analysis. We assessed the impact of potentially prognostic factors on bladder recurrence after RNU.Results.The median follow-up period was 47.8 months. In the Cox model, ureteral involvement and diabetes mellitus (DM) were significantly associated with a higher bladder recurrence rate in the multivariate analysis (hazard ratio [HR]: 1.838;P=0.003and HR: 1.821;P=0.010, resp.). In the Kaplan-Meier analysis, DM patients with concomitant ureteral UC experienced about a threefold increased risk of bladder recurrence as compared to those without both factors (HR: 3.222;P<0.001). Patients with either of the two risk factors experienced about a twofold increased risk as compared to those without both factors (with DM, HR: 2.184,P=0.024; with ureteral involvement, HR: 2.006,P=0.003).Conclusions.Ureteral involvement and DM are significantly related to bladder recurrence after RNU in patients with UUT-UC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Article Subject
medicine.medical_treatment
Urology
lcsh:Medicine
lcsh:RC870-923
urologic and male genital diseases
Nephrectomy
General Biochemistry, Genetics and Molecular Biology
Disease-Free Survival
Diabetes mellitus
Diabetes Mellitus
Medicine
Humans
In patient
Urothelium
Survival rate
Ureteral neoplasm
Urothelial carcinoma
Upper urinary tract
Aged
Retrospective Studies
Aged, 80 and over
General Immunology and Microbiology
business.industry
Proportional hazards model
Ureteral Neoplasms
lcsh:R
Hazard ratio
General Medicine
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
female genital diseases and pregnancy complications
Survival Rate
Neck of urinary bladder
Increased risk
Urinary Bladder Neoplasms
Concomitant
Female
Neoplasm Recurrence, Local
business
Research Article
Follow-Up Studies
Subjects
Details
- ISSN :
- 18795226
- Volume :
- 26
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Urological Science
- Accession number :
- edsair.doi.dedup.....a1d523ef2f5188e5361d4d89e9cc7ba1
- Full Text :
- https://doi.org/10.1016/j.urols.2015.06.250