Energy Expenditure Measurements in Ventilated Critically III Children: Within- and Between-Day Variability

Energy expenditure measurement (EEM) by indirect calorimetry is used as a research and clinical tool in pediatric intensive care units. The aims of the study were to determine if a 30-minute EEM is representative of a 24-hour EEM (within-day variation); to determine if there is any diurnal variation during the 24-hour period of EEM; and to determine if there is a clinically significant between day variation of EEMs.To determine within-day variation, energy expenditure was measured for a period of 24 hours for each subject (n = 11). The 24-hour period was then divided into 30-minute periods. The 30-minute means were compared with the 24-hour means. To determine between-day variation, EEMs were made daily for 30 minutes.In the within-day study, the overall mean percent coefficient of variation of the 30-minute measurements was 7.2% +/- 4.5%. There was no significant difference between the 30-minute means and the 24-hour means for each patient (p.691). In 8 subjects the 30-minute means did not differ from the 24-hour mean by more than 20%. No diurnal variation was observed. The mean percent variation of between day EEM was 21% +/- 16%; the range was 1% to 69%.In critically ill ventilated children, clinically relevant within-day variations in EEM are uncommon and a single 30-minute EEM gives an acceptable guide to the level of nutrition support required. Between-day variations can, however, be large and daily EEMs are required.