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Mechanism of Conversion of the Salmonella O Antigen by Bacteriophage ε34
- Publication Year :
- 1971
-
Abstract
- The structural determinants for antigen 34 in the E group salmonella are glucosyl substituents on the galactosyl units of the O antigen which has a mannosylrhamnosylgalactose repeating sequence. The temperate bacteriophage ε 34 brings about the production of antigen 34. It has been shown here that glucose is transferred from uridine diphosphate glucose to the O antigen via a glucosyl-lipid intermediate in a two-step reaction. Glucose is linked through carbon 1 to the lipid by a phosphodiester bridge, the glucosyl bond having the β-anomeric configuration. The lipid is a C 55 -polyisoprenoid alcohol, each isoprene unit having one double bond. It is the same lipid which is involved in the synthesis of the O antigen repeating sequence.
- Subjects :
- Electrophoresis
Lipopolysaccharides
Paper
Double bond
Chemical Phenomena
Rhamnose
Stereochemistry
Chromatography, Paper
Genetics and Molecular Biology
Tritium
Microbiology
Chromatography, DEAE-Cellulose
Bacteriophage
Electron Transport
chemistry.chemical_compound
Antigen
Salmonella
Lysogenic cycle
Antigens
Molecular Biology
Lysogeny
chemistry.chemical_classification
Carbon Isotopes
biology
Spectrum Analysis
Phosphorus Isotopes
Nucleosides
biology.organism_classification
carbohydrates (lipids)
Paper chromatography
Chemistry
Glucose
chemistry
Biochemistry
Phosphodiester bond
Mutation
Uridine diphosphate glucose
lipids (amino acids, peptides, and proteins)
Salmonella Phages
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a1c5cc575edf57f3a84f1f9a80e1cdbe