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Quantifying Antibody Persistence After a Single Dose of <scp>COVID</scp> ‐19 Vaccine Ad26. <scp>COV2</scp> .S in Humans Using a Mechanistic Modeling and Simulation Approach
- Source :
- Clinical Pharmacology & Therapeutics. 113:380-389
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Understanding persistence of humoral immune responses elicited by vaccination against coronavirus disease 2019 (COVID-19) is critical for informing the duration of protection and appropriate booster timing. We developed a mechanistic model to characterize the time course of humoral immune responses in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-seronegative adults after primary vaccination with the Janssen COVID-19 vaccine, Ad26.COV2.S. The persistence of antibody responses was quantified through mechanistic modeling-based simulations. Two biomarkers of humoral immune responses were examined: SARS-CoV-2 neutralizing antibodies determined by wild-type virus neutralization assay (wtVNA) and spike protein-binding antibodies determined by indirect spike protein enzyme-linked immunosorbent assay (S-ELISA). The persistence of antibody responses was defined as the period of time during which wtVNA and S-ELISA titers remained above the lower limit of quantification. A total of 442 wtVNA and 1,185 S-ELISA titers from 82 and 220 participants, respectively, were analyzed following administration of a single dose of Ad26.COV2.S (5 × 10
- Subjects :
- Pharmacology
Pharmacology (medical)
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....a1c034360048a6a8989099ee9fdf42d1
- Full Text :
- https://doi.org/10.1002/cpt.2796