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Quantifying Antibody Persistence After a Single Dose of <scp>COVID</scp> ‐19 Vaccine Ad26. <scp>COV2</scp> .S in Humans Using a Mechanistic Modeling and Simulation Approach

Authors :
Anna Dari
Muriel Boulton
Martine Neyens
Mathieu Le Gars
Belén Valenzuela
Georgi Shukarev
Vicky Cárdenas
Javier Ruiz‐Guiñazú
Jerald Sadoff
Richard M. W. Hoetelmans
Juan José Pérez Ruixo
Source :
Clinical Pharmacology & Therapeutics. 113:380-389
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Understanding persistence of humoral immune responses elicited by vaccination against coronavirus disease 2019 (COVID-19) is critical for informing the duration of protection and appropriate booster timing. We developed a mechanistic model to characterize the time course of humoral immune responses in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-seronegative adults after primary vaccination with the Janssen COVID-19 vaccine, Ad26.COV2.S. The persistence of antibody responses was quantified through mechanistic modeling-based simulations. Two biomarkers of humoral immune responses were examined: SARS-CoV-2 neutralizing antibodies determined by wild-type virus neutralization assay (wtVNA) and spike protein-binding antibodies determined by indirect spike protein enzyme-linked immunosorbent assay (S-ELISA). The persistence of antibody responses was defined as the period of time during which wtVNA and S-ELISA titers remained above the lower limit of quantification. A total of 442 wtVNA and 1,185 S-ELISA titers from 82 and 220 participants, respectively, were analyzed following administration of a single dose of Ad26.COV2.S (5 &#215; 10

Details

ISSN :
15326535 and 00099236
Volume :
113
Database :
OpenAIRE
Journal :
Clinical Pharmacology & Therapeutics
Accession number :
edsair.doi.dedup.....a1c034360048a6a8989099ee9fdf42d1
Full Text :
https://doi.org/10.1002/cpt.2796