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Outcomes of HIV-Infected Orphaned and Non-Orphaned Children on Antiretroviral Therapy in Western Kenya
- Source :
- JAIDS Journal of Acquired Immune Deficiency Syndromes. 43:418-425
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- The objectives were to determine outcome differences between orphaned and non-orphaned children receiving antiretroviral therapy (ART). Design: Retrospective review of prospectively recorded electronic data. Setting: Nine HIV clinics in western Kenya. Population: 279 children on ART enrolled between August 2002 and February 2005. Main Measures: Orphan status CD4% sex- and age-adjusted height (HAZ) and weight (WAZ) z scores ART adherence mortality. Median follow-up was 34 months. Cohort included 51% males and 54% orphans. At ART initiation (baseline) 71% of children had CDC clinical stage B or C disease. Median CD4% was 9% and increased dramatically the first 30 weeks of therapy then leveled off. Parents and guardians reported perfect adherence at every visit for 75% of children. Adherence and orphan status were not significantly associated with CD4% response. Adjusted for baseline age follow-up was significantly shorter among orphaned children (median 33 vs. 41 weeks P = 0.096). One-year mortality was 7.1% for orphaned and 6.6% for non-orphaned children (P = 0.836). HAZ and WAZ were significantly below norm in both groups. With ART HAZ remained stable while WAZ tended to increase toward the norm especially among non-orphans. Orphans showed identical weight gains as non-orphans the first 70 weeks after start of ART but experienced reductions afterwards. Good ART adherence is possible in western rural Kenya. ART for HIV-infected children produced substantial and sustainable CD4% improvement. Orphan status was not associated with worse short-term outcomes but may be a factor for long-term therapy response. ART alone may not be sufficient to reverse significant developmental lags in the HIV-positive pediatric population. (authors)
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
Anti-HIV Agents
Population
HIV Infections
Foster Home Care
Orphan drug
Acquired immunodeficiency syndrome (AIDS)
Humans
Medicine
Body Weights and Measures
Pharmacology (medical)
Child
Sida
education
education.field_of_study
biology
business.industry
Infant
Retrospective cohort study
biology.organism_classification
medicine.disease
Kenya
CD4 Lymphocyte Count
Treatment Outcome
Infectious Diseases
El Niño
Child, Preschool
Cohort
HIV-1
Female
Electronic data
business
Subjects
Details
- ISSN :
- 15254135
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Accession number :
- edsair.doi.dedup.....a1b41fb683bdd7358ade81c2279112b5