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A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab
- Source :
- Drug Target Insights, Vol 2016, Iss 10, Pp 9-12 (2016), Drug Target Insights, Vol 10 (2016), Drug Target Insights, Vol 10, Iss 1 (2016), Drug Target Insights
- Publication Year :
- 2016
- Publisher :
- AboutScience Srl, 2016.
-
Abstract
- Until recently, chemotherapy for metastatic melanoma had disappointing results. The identification of immune checkpoints such as CTLA-4 and PD-1/PD-L1 has led to the development of an array of monoclonal antibodies (Mabs). These immunologic approaches against tumoral cells come with a novel kind of side effects that the clinician needs to be familiarized with. Herein, we report for the first time a case of organizing pneumonia, based on imaging and cytological analyses of bronchoalveolar lavage, possibly associated with the use of pembrolizumab, an anti-PD-1 Mab recently approved for the treatment of metastatic melanoma.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Pathology
Side effect
side effect
medicine.drug_class
organizing pneumonia
medicine.medical_treatment
Clinical Biochemistry
Case Report
Pembrolizumab
Monoclonal antibody
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
melanoma
Medicine
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Chemotherapy
medicine.diagnostic_test
business.industry
Melanoma
lcsh:RM1-950
Cancer
General Medicine
medicine.disease
OP
030104 developmental biology
Bronchoalveolar lavage
lcsh:Therapeutics. Pharmacology
030220 oncology & carcinogenesis
pembrolizumab
business
Subjects
Details
- Language :
- English
- ISSN :
- 11773928
- Volume :
- 2016
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Drug Target Insights
- Accession number :
- edsair.doi.dedup.....a1ac24395f81fe2049d6b68a47c883e6