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Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression
- Source :
- The Journal of dairy research. 76(3)
- Publication Year :
- 2009
-
Abstract
- Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture,Lactococcus lactisDPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed inInterleukin(IL)-1β andIL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of aLc. lactisleads to a rapid and considerable innate immune response.
- Subjects :
- medicine.drug_class
Antibiotics
Interleukin-1beta
Gene Expression
Cell Count
Mastitis
Biology
Microbiology
Immune system
Probiotic treatment
Mammary Glands, Animal
medicine
Animals
Udder
Mastitis, Bovine
Innate immune system
Lactococcus lactis
Interleukin-8
Vaccination
Interleukin
General Medicine
medicine.disease
biology.organism_classification
medicine.anatomical_structure
Milk
Immunology
Animal Science and Zoology
Cattle
Female
Somatic cell count
Food Science
Subjects
Details
- ISSN :
- 14697629
- Volume :
- 76
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of dairy research
- Accession number :
- edsair.doi.dedup.....a1a794d48229a7c7affa0292b9a4ee1a