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Current surgical management in RET mutation carriers [Aktualne postępowanie chirurgiczne u nosicieli mutacji proto-onkogenu RET]
- Source :
- Endokrynologia Polska. 70(4)
- Publication Year :
- 2019
-
Abstract
- Medullary thyroid carcinoma (MTC) still remains a rare endocrine tumor. 20-25% of MTC cases are genetically determined. The detection of the RET proto-oncogene mutation in 1993 allowed to understand the unique genotype-phenotype relationships in hereditary medullary thyroid carcinoma (HMTC) and formed the basis for therapeutic decisions based on the molecular results. Currently, prophylactic thyroidectomy is a commonly adopted and accepted therapeutic method. The decision on the time and extent of surgery should be made based on the results of molecular examination, the assessment of calcitonin (Ct) concentration and family history. Treatment of patients with HMTC requires the cooperation of a multidisciplinary team of experts and should be done in specialized centers only. The study is a review of the current guidelines for surgical management in the MEN2 syndrome.
- Subjects :
- Oncology
Calcitonin
medicine.medical_specialty
Ret gene
Endocrine Tumor
Medullary cavity
Endocrinology, Diabetes and Metabolism
Multiple Endocrine Neoplasia Type 2a
Multidisciplinary team
Proto-Oncogene Mas
Thyroid carcinoma
Endocrinology
Internal medicine
medicine
Humans
Thyroid Neoplasms
Family history
business.industry
Proto-Oncogene Proteins c-ret
Disease Management
Carcinoma, Medullary
Mutation
Practice Guidelines as Topic
Thyroidectomy
Prophylactic thyroidectomy
business
Subjects
Details
- ISSN :
- 22998306
- Volume :
- 70
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Endokrynologia Polska
- Accession number :
- edsair.doi.dedup.....a1a361ba6616c1cf78c7d301c98192db