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Current surgical management in RET mutation carriers [Aktualne postępowanie chirurgiczne u nosicieli mutacji proto-onkogenu RET]

Authors :
Agnieszka Czarniecka
Marcin Zeman
Anna Hajduk
Barbara Jarzab
Malgorzata Oczko-Wojciechowska
Source :
Endokrynologia Polska. 70(4)
Publication Year :
2019

Abstract

Medullary thyroid carcinoma (MTC) still remains a rare endocrine tumor. 20-25% of MTC cases are genetically determined. The detection of the RET proto-oncogene mutation in 1993 allowed to understand the unique genotype-phenotype relationships in hereditary medullary thyroid carcinoma (HMTC) and formed the basis for therapeutic decisions based on the molecular results. Currently, prophylactic thyroidectomy is a commonly adopted and accepted therapeutic method. The decision on the time and extent of surgery should be made based on the results of molecular examination, the assessment of calcitonin (Ct) concentration and family history. Treatment of patients with HMTC requires the cooperation of a multidisciplinary team of experts and should be done in specialized centers only. The study is a review of the current guidelines for surgical management in the MEN2 syndrome.

Details

ISSN :
22998306
Volume :
70
Issue :
4
Database :
OpenAIRE
Journal :
Endokrynologia Polska
Accession number :
edsair.doi.dedup.....a1a361ba6616c1cf78c7d301c98192db