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Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation
- Source :
- Diabetes
- Publication Year :
- 2020
- Publisher :
- American Diabetes Association, 2020.
-
Abstract
- Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and related metabolic diseases remains elusive. In this study, we show that adipocyte-specific Becn1 knockout mice develop severe lipodystrophy, leading to adipose tissue inflammation, hepatic steatosis, and insulin resistance. Ablation of Becn1 in adipocytes stimulates programmed cell death in a cell-autonomous manner, accompanied by elevated endoplasmic reticulum (ER) stress gene expression. Furthermore, we observed that Becn1 depletion sensitized mature adipocytes to ER stress, leading to accelerated cell death. Taken together, these data suggest that adipocyte Becn1 would serve as a crucial player for adipocyte survival and adipose tissue homeostasis.
- Subjects :
- 0301 basic medicine
Programmed cell death
Lipodystrophy
Endocrinology, Diabetes and Metabolism
Adipose Tissue, White
Adipose tissue
030209 endocrinology & metabolism
White adipose tissue
Biology
Pathophysiology
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Metabolic Diseases
Adipocyte
Internal Medicine
medicine
Adipocytes
Animals
Homeostasis
Inflammation
Mice, Knockout
BECN1
medicine.disease
Cell biology
Fatty Liver
030104 developmental biology
chemistry
Unfolded protein response
Beclin-1
Steatosis
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1939327X and 00121797
- Volume :
- 70
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....a1a0abf2458faed7a94ef2bcbd62a42e