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The relationship between atrophy and hypometabolism: is it regionally dependent in dementias?
The relationship between atrophy and hypometabolism: is it regionally dependent in dementias?
- Source :
- Current neurology and neuroscience reports. 15(7)
- Publication Year :
- 2015
-
Abstract
- Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific patterns of hypometabolism, even in the absence of atrophy, which are currently considered as diagnostic biomarkers. Atrophy is less consistently found as an initial marker of these diseases and is invariably present in moderate to severe stages with a disease-related topography. The relationship between these two markers is not uniform, but in the two diseases in which they have been directly compared, Alzheimer's and Parkinson's disease, altered hypometabolism precedes and exceeds atrophy in most regions. This suggests a two-step degenerative process. In contrast to these findings, the hippocampus skips this pattern and is more structurally than functionally affected, thereby suggesting a different pathological mechanism in this particular area. More studies are needed to disentangle the mechanisms underlying both markers and their relationship in neurodegenerative diseases.
- Subjects :
- Metabolic Syndrome
medicine.medical_specialty
Pathology
Neurology
General Neuroscience
Hippocampus
Parkinson Disease
Disease
Grey matter
medicine.disease
Atrophy
medicine.anatomical_structure
medicine
Dementia
Humans
Cognitive Dysfunction
Neurology (clinical)
Cognitive decline
Psychology
Pathological
Neuroscience
Subjects
Details
- ISSN :
- 15346293
- Volume :
- 15
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Current neurology and neuroscience reports
- Accession number :
- edsair.doi.dedup.....a18f240c14b96c099c937ce2b05d01eb