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Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study
- Source :
- Acta Dermato-Venereologica, Vol 99, Iss 13, Pp 1224-1230 (2019), Loft, N D, Egeberg, A, Rasmussen, M K, Bryld, L E, Gniadecki, R, Dam, T N, Iversen, L & Skov, L 2019, ' Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis : A Danish Nationwide Study ', Acta Dermato-Venereologica, vol. 99, no. 13, pp. 1224-1230 . https://doi.org/10.2340/00015555-3331
- Publication Year :
- 2019
- Publisher :
- Medical Journals Sweden, 2019.
-
Abstract
- The initiation and evaluation of treatment with biologics for psoriasis is based on the Psoriasis Area Severity Index (PASI) and/or Dermatological Life Quality Index (DLQI). However, these indices do not always correlate well, and changes in the DLQI do not always follow changes in the PASI. Based on data from the Danish national registry (DERMBIO), this study investigated the correlation between changes in PASI and DLQI in a cohort of patients with moderate-to-severe psoriasis treated with biologics or apremilast using Spearman’s rank correlation analyses. The correlation analysis of 1,677 patients, of whom 276 had available data after 5 years, showed weak-to-moderate correlation between PASI and DLQI during a 5-year period and between changes in PASI and DLQI: 0.58 (p
- Subjects :
- Male
Denmark
Severity of Illness Index
030207 dermatology & venereal diseases
Psoriasis Area and Severity Index
0302 clinical medicine
Quality of life
Registries
Age Factors
General Medicine
Dermatology Life Quality Index
psoriasis
Middle Aged
humanities
Thalidomide
Treatment Outcome
patient-reported outcomes
RL1-803
Cohort
medicine.drug
Adult
medicine.medical_specialty
Dermatology
Risk Assessment
Drug Administration Schedule
Statistics, Nonparametric
03 medical and health sciences
Sex Factors
Psoriasis
medicine
Humans
biologics
Patient Reported Outcome Measures
Rank correlation
030203 arthritis & rheumatology
Biological Products
Dose-Response Relationship, Drug
business.industry
Arthritis, Psoriatic
Life Quality Index
dermatology life quality index
medicine.disease
Quality of Life
Apremilast
sense organs
psoriasis area and severity index
business
Subjects
Details
- Language :
- English
- ISSN :
- 16512057 and 00015555
- Volume :
- 99
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Acta Dermato-Venereologica
- Accession number :
- edsair.doi.dedup.....a18a3825f4b56e9664cb229e7c83af70