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Assessment of hepatoprotective potential of Radix Fici Hirtae on alcohol-induced liver injury in Kunming mice

Authors :
Kangxian Li
Wu Xiaosong
Ye Yingting
Li Shasha
Lai Yongjun
Jing Huang
Lingfeng Zeng
Mei Zhu
Fangming Tan
Feng Xiaofei
Jieyi Zhou
Source :
Biochemistry and Biophysics Reports, Biochemistry and Biophysics Reports, Vol 16, Iss, Pp 69-73 (2018)
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

Objective: The objective of the present study was to investigate the hepatoprotective role of Radix Fici Hirtae on acute alcohol-induced liver injury in mice. Methods: The component of Radix Fici Hirtae was extracted using petroleum ether, chloroform, ethyl acetate and n-butanol and divided into three dose groups of high, medium and low according to the clinical man's normal dose of the 50 g crude drug/d (0.83 g/kg body weight). Saline in concentration of 10 mg/mL, 5 mg/mL and 2.5 mg/mL and a dose of mouse lavage (0.2 mL/10 g mouse body weight) were added to the solution. Histopathlogical analysis of liver was performed. Finally, liver protection was validated by examining the effect of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and lactate dehydrogenase (LDH) on the hepatic function of mice in alcohol-induced liver injury model. Results: Except for group with saturated n-butyl alcohol, for the rest of the groups, pathological changes of hepatic lipid and inflammatory cells infiltration were alleviated and liver sinus was normal. As compared to model group, the concentrations of AST, ALT, AKP and LDH in chloroform groups and ethyl acetate groups were significantly decreased. Conclusions: Extracts of Radix Fici Hirtae are effective for the prevention of alcohol-induced hepatic damage in mice. The results revealed that extracts of Radix Fici Hirtae could be used as hepatoprotective agent. Keywords: Radix Fici Hirtae, Alcohol-induced liver injury, Hepatoprotective

Details

ISSN :
24055808
Volume :
16
Database :
OpenAIRE
Journal :
Biochemistry and Biophysics Reports
Accession number :
edsair.doi.dedup.....a17b9ebfc8cdbfb6f579b678de18c503
Full Text :
https://doi.org/10.1016/j.bbrep.2018.10.003