Back to Search
Start Over
Effects of Duchenne muscular dystrophy on muscle stiffness and response to electrically-induced muscle contraction: A 12-month follow-up
- Source :
- Neuromuscular Disorders, Neuromuscular Disorders, Elsevier, 2017, 27 (3), pp.214-220. ⟨10.1016/j.nmd.2017.01.001⟩, Neuromuscular Disorders, 2017, 27 (3), pp.214-220. ⟨10.1016/j.nmd.2017.01.001⟩
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The present study aimed to assess the ability of muscle stiffness (shear modulus) and response to electrically-induced muscle contraction to detect changes in muscle properties over a 12-month period in children with Duchenne muscular dystrophy (DMD). Ten children with DMD and nine age-matched healthy male controls participated in two experimental sessions (T 0 and T +12months ) separated by 12.4 ± 0.9 months. Two contractions of the biceps brachii were electrically-induced during which an ultrasound probe was placed over the muscle. The resting shear modulus was measured using elastography from six muscles. Evoked maximal torque was increased at T +12months in controls (+11.2 ± 7.6%, P 0.001) but was not modified in children with DMD ( P = 0.222). Electromechanical delay (+12.9 ± 11.3%, P 0.001) and its force transmission component (+10.1 ± 21.6%, P = 0.003) were significantly longer at T +12months than T 0 for children with DMD. The results revealed an increase in muscle stiffness at T +12months in children with DMD for tibialis anterior (+75.1 ± 93.5%, P = 0.043), gastrocnemius medialis (+144.8 ± 180.6%, P = 0.050) and triceps brachii (+35.5 ± 32.2%, P = 0.005). This 12-month follow-up study demonstrates that electromechanical delay and elastography may help detect subtle muscle impairments in patients with DMD. These sensitive outcomes may improve the follow-up of innovative therapeutic interventions within the field of DMD.
- Subjects :
- Adult
Male
musculoskeletal diseases
Ultrafast ultrasound
medicine.medical_specialty
Adolescent
Myopathy
[SDV]Life Sciences [q-bio]
Duchenne muscular dystrophy
MESH: Adolescent Adult Child Elasticity Imaging Techniques Electric Stimulation Follow-Up Studies Humans Male Muscle Contraction / physiology* Muscle, Skeletal / diagnostic imaging Muscle, Skeletal / physiopathology* Muscular Dystrophy, Duchenne / diagnostic imaging Muscular Dystrophy, Duchenne / physiopathology* Ultrasonography Young Adult
Biceps
Young Adult
Electromechanical delay
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
Child
Muscle, Skeletal
Genetics (clinical)
Ultrasonography
medicine.diagnostic_test
business.industry
030229 sport sciences
Anatomy
Muscle stiffness
medicine.disease
Electric Stimulation
Muscular Dystrophy, Duchenne
Neurology
Pediatrics, Perinatology and Child Health
Cardiology
Elasticity Imaging Techniques
Neurology (clinical)
Elastography
Evoked muscle force
medicine.symptom
business
030217 neurology & neurosurgery
Follow-Up Studies
Muscle Contraction
Month follow up
Muscle contraction
Subjects
Details
- ISSN :
- 09608966
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Neuromuscular Disorders
- Accession number :
- edsair.doi.dedup.....a176684a602bded590083fe3538780e4