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Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes
- Source :
- Fishes, Volume 3, Issue 4, Pages 46-0, Fishes, Vol 3, Iss 4, Pp 46-0 (2018)
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- There are a number of different animals that belong to long- and short-lived species and show a various rate of ageing, providing an ideal model to investigate mechanisms of longevity. In this work, a metabolome profiling of blood plasma from fishes with various ageing rates—negligible (Pike Esox Lucius and Sterlet Acipenser ruthenus), gradual (Zander Sander lucioperca and Perch Perca fluviatilis) and rapid (Chum Salmon Oncorhynchus keta and Pink Salmon Oncorhynchus gorbuscha)—was assessed by means of direct infusion to quadrupole time-of-flight mass spectrometry. Of the 2056 distinct m/z features detected by a mass spectrometry metabolic profiling of blood plasma samples, fifteen metabolites in the classes of dipeptides, fatty acids, glycerolipids, phosphoethanolamines and phosphatidylcholines were significantly associated with ageing rate, independent of species differences. This is the first study of the metabolome of fishes with various ageing rate, and this untargeted approach highlighted the metabolic conditions that may serve to assess the ageing process.
- Subjects :
- 0301 basic medicine
lcsh:QH426-470
Zoology
Aquatic Science
03 medical and health sciences
blood plasma metabolites
0302 clinical medicine
metabolome profiling
Blood plasma
Metabolome
Acipenser ruthenus
lcsh:QH301-705.5
Ecology, Evolution, Behavior and Systematics
Esox
Pike
computer.programming_language
fish
Perch
Ecology
biology
Chemistry
biology.organism_classification
type of senescence
lcsh:Genetics
030104 developmental biology
lcsh:Biology (General)
Ageing
ageing
Oncorhynchus
computer
030217 neurology & neurosurgery
negligible ageing
Subjects
Details
- Language :
- English
- ISSN :
- 24103888
- Database :
- OpenAIRE
- Journal :
- Fishes
- Accession number :
- edsair.doi.dedup.....a170f55634ad26ef74b64e8055964aaf
- Full Text :
- https://doi.org/10.3390/fishes3040046