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Cannabinoid receptor 2-63 RR variant is independently associated with severe necroinflammation in HIV/HCV coinfected patients
- Source :
- PLoS ONE, Vol 12, Iss 7, p e0181890 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science, 2017.
-
Abstract
- Objective: This is the first study to analyze the impact of the rs35761398 variant of the CNR2 gene leading to the substitution of GLN (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with ARG (R) on the clinical presentation of chronic hepatitis in HIV/HCV coinfected patients. Methods: Enrolled in this study were 166 consecutive HIV/HCV coinfected patients, naïve for HCV treatment. A pathologist unaware of the patientsâ condition graded liver fibrosis, necroinflammation (Ishak) and steatosis. All patients were screened for the CB2 rs35761398 polymorphism. Results: Of the 166 HIV/HCV coinfected patients, 72.9% were males, 42.5% were infected with HCV-genotype-3 and 60.2% had been intravenous drug users. The median age was 40.6 years and the immunological condition good (median CD4+cells/mm3= 507, IQR: 398.0â669.5). Thirty-five (21.1%) patients were naive for ART and 131(78.9%) were on ART. The CB2-RR variant was detected in 45.8% of patients, QR in 38.6% and QQ in 15.7%. Patients with CB2-RR showed a necroinflammation score (HAI) â¥9 more frequently than those with CB2-QQ or CB2-QR (32.9% vs. 11.5% and 14.1%, respectively, pâ¤0.001). In the multivariate analysis, the CB2-RR variant (p = 0.03) and liver fibrosis were both identified as independent predictors of the entity of liver necroinflammation (p = 0.0001). Conclusion: This study shows interesting interplay between the CB2-RR variant and liver necroinflammation in chronic hepatitis patients with HIV/HCV coinfection, an observation of clinical value that coincides with the interest in the use of the CB2 agonists and antagonists in clinical practice emerging from the literature.
- Subjects :
- RNA viruses
Liver Cirrhosis
0301 basic medicine
Male
Chronic Hepatitis
Steatosis
Hepacivirus
Biopsy
lcsh:Medicine
HIV Infections
Pathology and Laboratory Medicine
medicine.disease_cause
Gastroenterology
Chronic Liver Disease
Cytopathology
Receptor, Cannabinoid, CB2
0302 clinical medicine
Immunodeficiency Viruses
Gene Frequency
Fibrosis
Medicine and Health Sciences
HIV Infection
lcsh:Science
Multivariate Analysi
Allele
Multidisciplinary
medicine.diagnostic_test
biology
Hepatitis C virus
Coinfection
Liver Diseases
Medicine (all)
Fatty liver
Hepatitis C
Medical microbiology
Middle Aged
Liver
Viruses
Liver Fibrosis
lipids (amino acids, peptides, and proteins)
030211 gastroenterology & hepatology
Female
Pathogens
Research Article
Human
Adult
medicine.medical_specialty
Genotype
Liver Cirrhosi
Surgical and Invasive Medical Procedures
Gastroenterology and Hepatology
Microbiology
Polymorphism, Single Nucleotide
03 medical and health sciences
Internal medicine
Retroviruses
medicine
Humans
Codon
Alleles
Inflammation
Hepaciviru
Biochemistry, Genetics and Molecular Biology (all)
Biology and life sciences
Flaviviruses
business.industry
Lentivirus
lcsh:R
Organisms
Viral pathogens
HIV
Hepatitis C, Chronic
medicine.disease
biology.organism_classification
Hepatitis viruses
Microbial pathogens
Fatty Liver
030104 developmental biology
Agricultural and Biological Sciences (all)
Anatomical Pathology
Multivariate Analysis
lcsh:Q
business
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 12, Iss 7, p e0181890 (2017), PLoS ONE
- Accession number :
- edsair.doi.dedup.....a167e3a67054477e1e54950f63cecb2f