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Glucose-stimulated sodium transport by the human intestine during experimental cholera
- Source :
- Gastroenterology. 112:1529-1535
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- BACKGROUND & AIMS: Net sodium absorption from oral rehydration solution is increased by both glucose-sodium cotransport and solvent drag. The aim of this study was to measure the relative importance of glucose- sodium cotransport and solvent drag in the stimulation of net sodium absorption by oral rehydration solution. METHODS: Total intestinal perfusion was used in normal subjects with and without intrajejunal cholera toxin using three test solutions containing 100 mmol/L sodium and either 100 mmol/L mannitol (control), 100 mmol/L glucose, or no additional solute (hypotonic solution). The increase in sodium absorption greater than control with hypotonic solution represented sodium absorption stimulated by solvent drag; the further increase in sodium absorption induced by glucose, greater than that noted with the hypotonic solution, represented sodium absorption stimulated by cotransport. RESULTS: Without cholera toxin, solvent drag and cotransport promoted sodium absorption at rates of 62 and 33 mmol/h, respectively. With cholera toxin, solvent drag and cotransport promoted sodium absorption at rates of 44 and 71 mmol/h, respectively. CONCLUSIONS: Net sodium absorption caused by cotransport increased more than twofold after exposure of the intestine to cholera toxin (P < 0.003). This could be mediated by increased cotransport, a change in the stoichiometry of cotransport, or an increase in chloride permeability. (Gastroenterology 1997 May;112(5):1529-35)
- Subjects :
- Adult
Absorption (pharmacology)
Cholera Toxin
medicine.medical_specialty
Monosaccharide Transport Proteins
Sodium
chemistry.chemical_element
medicine.disease_cause
chemistry.chemical_compound
Cholera
Solvent drag
Internal medicine
medicine
Humans
Intestinal Mucosa
Ion transporter
Chromatography
Hepatology
urogenital system
Cholera toxin
Gastroenterology
Middle Aged
Endocrinology
Hypotonic Solutions
Intestinal Absorption
L-Glucose
chemistry
Solvents
Mannitol
Cotransporter
medicine.drug
Subjects
Details
- ISSN :
- 00165085
- Volume :
- 112
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....a167a099374a6b4f768ae4900cb74236