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Partial wrapping and spontaneous endocytosis of spherical nanoparticles by tensionless lipid membranes
- Source :
- The Journal of chemical physics. 144(4)
- Publication Year :
- 2016
-
Abstract
- Computer simulations of an implicit-solvent particle-based model are performed to investigate the interactions between small spherical nanoparticles and tensionless lipid bilayers. We found that nanoparticles are either unbound, wrapped by the bilayer, or endocytosed. The degree of wrapping increases with increasing the adhesion strength. The transition adhesion strength between the unbound and partially wrapped states decreases as the nanoparticle diameter is increased. We also observed that the transition adhesion strength between the wrapped states and endocytosis state decreases with increasing the nanoparticle diameter. The partial wrapping of the nanoparticles by the tensionless bilayer is explained by an elastic theory which accounts for the fact that the interaction between the nanoparticle and the bilayer extends beyond the contact region. The theory predicts that for small nanoparticles, the wrapping angle increases continuously with increasing the adhesion strength. However, for relatively large nanoparticles, the wrapping angle exhibits a discontinuity between weakly and strongly wrapped states. The size of the gap in the wrapping angle between the weakly wrapped and strongly wrapped states increases with decreasing the range of nanoparticle-bilayer interaction.
- Subjects :
- Materials science
Lipid Bilayers
General Physics and Astronomy
Nanoparticle
02 engineering and technology
macromolecular substances
010402 general chemistry
Endocytosis
01 natural sciences
Adhesion strength
ARTICLES
Physical and Theoretical Chemistry
Composite material
Lipid bilayer
Bilayer
technology, industry, and agriculture
Contact region
Models, Theoretical
021001 nanoscience & nanotechnology
equipment and supplies
0104 chemical sciences
Crystallography
Membrane
biological sciences
Nanomedicine
Nanoparticles
0210 nano-technology
Subjects
Details
- ISSN :
- 10897690
- Volume :
- 144
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of chemical physics
- Accession number :
- edsair.doi.dedup.....a16445bc244ae493198d6342a92a5d35