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Autoantibodies to C-reactive protein (CRP) and other acute-phase proteins in systemic autoimmune diseases
- Source :
- Clinical and Experimental Immunology. 113:327-332
- Publication Year :
- 1998
- Publisher :
- Oxford University Press (OUP), 1998.
-
Abstract
- SUMMARYAutoantibodies to CRP were reported previously in patients suffering from toxic oil syndrome. This syndrome resembles autoimmune diseases such as systemic lupus erythematosus (SLE) or systemic scleroderma. We therefore examined the prevalence of antibodies to CRP and other acute-phase proteins in autoimmune diseases, including SLE, subacute cutaneous lupus erythematosus (SCLE), systemic scleroderma (SSc), and primary biliary cirrhosis (PBC), as well as in bone marrow transplantation-induced chronic graft-versus-host disease and eosinophilia–myalgia syndrome. IgG antibodies to CRP were found in 78% of SLE and in 30% of SCLE patients, while 16% of patients with PBC were positive. In up to 45% of patients with SSc predominantly IgG antibodies to ceruloplasmin were detectable. Lack of systemic involvement as in discoid lupus erythematosus and localized scleroderma (morphea) correlated with low or absent antibody formation. However, no correlation was found between anti-acute-phase protein antibodies with liver disease or other organ involvement. Adsorption studies revealed that non-native epitopes on the CRP molecule, termed modified CRP, are the main target of antibodies. Chronic inflammatory tissue injury in systemic autoimmune disease might increase the presentation of cryptic epitopes of CRP to the threshold required for T cell activation.
- Subjects :
- Anti-nuclear antibody
Discoid lupus erythematosus
Immunology
Scleroderma
Autoimmune Diseases
Subacute cutaneous lupus erythematosus
Primary biliary cirrhosis
immune system diseases
medicine
Humans
Lupus Erythematosus, Systemic
Immunology and Allergy
skin and connective tissue diseases
Autoantibodies
Scleroderma, Systemic
Lupus erythematosus
business.industry
Autoantibody
medicine.disease
C-Reactive Protein
Immunoglobulin G
Original Article
business
Acute-Phase Proteins
Anti-SSA/Ro autoantibodies
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....a1618a1c6d35048056cac6258176cc26