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Full age spectrum equation versus CKD-EPI and MDRD equations to estimate glomerular filtration rate in adults with obstructive nephropathy
- Source :
- Journal of International Medical Research, Vol 47 (2019), The Journal of International Medical Research
- Publication Year :
- 2019
- Publisher :
- SAGE Publishing, 2019.
-
Abstract
- Objective To compare the full age spectrum (FAS) equation with the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in predicting glomerular filtration rate (GFR) in patients with obstructive nephropathy. Methods Adult patients with obstructive nephropathy who had undergone a GFR measurement using technetium-99m diethylenetriaminepentaacetic acid radioisotope renography were enrolled in the study. The measured GFR was taken as the reference value. Bias, precision and accuracy were compared between the three equations. Kappa test and the Bland–Altman method were used to evaluate the classification and the agreement. Receiver operating characteristic (ROC) curve analysis was used to describe the diagnostic accuracy of each equation. Results A total of 327 patients were enrolled. The P30 value for the FAS equation was 60.2% in the overall study cohort. The FAS equation had the highest diagnostic accuracy (ROCAUC = 0.87, 95% confidence interval [CI] 0.84, 0.91) compared with the MDRD equation (ROCAUC = 0.86, 95% CI 0.82, 0.89). The median bias of the FAS equation was significantly higher than that of the MDRD equation (8.7 versus 7.6 ml/min/1.73 m2, respectively). Conclusions Despite the drawbacks associated with each equation, the FAS equation was probably closer to ideal to estimate GFR in patients with obstructive nephropathy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Medicine (General)
Adolescent
Clinical Research Reports
030232 urology & nephrology
Urology
Renal function
equation
Disease
030204 cardiovascular system & hematology
Kidney Function Tests
urologic and male genital diseases
Biochemistry
Young Adult
03 medical and health sciences
0302 clinical medicine
R5-920
Epidemiology
medicine
Humans
Renal Insufficiency, Chronic
Retrospective Studies
glomerular filtration rate
business.industry
obstructive nephropathy
Biochemistry (medical)
Feeding Behavior
Mathematical Concepts
Cell Biology
General Medicine
Middle Aged
Models, Theoretical
Prognosis
medicine.disease
Obstructive Nephropathy
Full age spectrum
Creatinine
Female
business
Follow-Up Studies
Ureteral Obstruction
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 14732300 and 03000605
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....a15002e80103281c725f7b3e43c6d836