Back to Search
Start Over
Genetic polymorphisms of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India
- Source :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(5)
- Publication Year :
- 2013
-
Abstract
- Estrogen is a key driver of breast cancer and genes involved in its signaling and biosynthesis are crucial in breast cancer progression. In this study, we investigated the role of estrogen signaling and synthesis related genes polymorphism in susceptibility to breast cancer risk in North India population in a case–control approach. We examined the association of single nucleotide polymorphism (SNP) in estrogen receptors, ESR1 (rs2234693) and ESR2 (rs2987983); estrogen biosynthesis enzymes, CYP17A1 (rs743572); and aromatase, CYP19A1 (rs700519) with breast cancer risk. Cases (n = 360) were matched to controls (n = 360) by age, sex, ethnicity, and geographical location. Results provided evidence that all the genetic variants were significantly associated with breast cancer risk among North Indian women. Furthermore, on performing stratified analysis between breast cancer risk and different clinicopathological characteristics, we observed strong associations for menopausal status, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status, clinical stage, and histological grade. Our results suggest that these genes could be used as molecular markers to assess breast cancer susceptibility and predicting prognosis in North India population.
- Subjects :
- Oncology
Adult
Risk
medicine.medical_specialty
medicine.drug_class
Population
Estrogen receptor
India
Single-nucleotide polymorphism
Breast Neoplasms
Polymorphism, Single Nucleotide
Breast cancer
Aromatase
Internal medicine
medicine
Estrogen Receptor beta
Humans
Genetic Predisposition to Disease
skin and connective tissue diseases
education
Aged
education.field_of_study
biology
Case-control study
Estrogen Receptor alpha
Steroid 17-alpha-Hydroxylase
General Medicine
Middle Aged
medicine.disease
Endocrinology
Estrogen
Case-Control Studies
biology.protein
Female
Estrogen receptor alpha
Subjects
Details
- ISSN :
- 14230380
- Volume :
- 35
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....a143b553d2f3f5eead21906f2c24ee35