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Mechanisms of action and historical facts on the use of intravenous immunoglobulins in systemic lupus erythematosus
- Source :
- Autoimmunity Reviews. 18:279-286
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The current existing therapies for severe cases of systemic lupus erythematosus (SLE) patients are still limited. Intravenous immunoglobulin (IVIGs), which are purified from the plasma of thousands of healthy human donors, have been profiled as efficacious and life-saving options for SLE patients refractory to conventional therapy. The specific mechanism of action by which IVIGs generate immunomodulation in SLE is not currently understood. In this manuscript, we reviewed some of the hypothesis that have been postulated to explain the IVIG effects, including those on T and B cell intracellular signalling and activation, as well as the interferon signalling pathways involved in the detection of nucleic acids and the defective removal of immune complexes and debris.
- Subjects :
- 0301 basic medicine
T-Lymphocytes
Immunology
03 medical and health sciences
0302 clinical medicine
Immune system
immune system diseases
Interferon
hemic and lymphatic diseases
Animals
Humans
Immunologic Factors
Lupus Erythematosus, Systemic
Immunology and Allergy
Medicine
skin and connective tissue diseases
Intracellular signalling
B cell
030203 arthritis & rheumatology
B-Lymphocytes
biology
business.industry
Immunoglobulins, Intravenous
030104 developmental biology
medicine.anatomical_structure
Mechanism of action
Intravenous Immunoglobulins
biology.protein
Interferons
medicine.symptom
Antibody
business
Signalling pathways
medicine.drug
Subjects
Details
- ISSN :
- 15689972
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Autoimmunity Reviews
- Accession number :
- edsair.doi.dedup.....a12f14451cdaec71a9f8740714a72035