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Cross-Dehydrogenative Coupling Reaction and Arylation of Quinoxalin-2(1H)-ones under Iodide/Peroxide Conditions
- Source :
- SynOpen, Vol 05, Iss 02, Pp 114-122 (2021)
- Publication Year :
- 2021
- Publisher :
- Georg Thieme Verlag KG, 2021.
-
Abstract
- A simple method has been developed for the synthesis of ­3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-one and ­3-aryl-quinoxalin-2(1H)-one derivatives through C–H activation of quinoxalin-2(1H)-ones by peroxides and iodide. In this protocol, the per­oxide (TBPB) serves as both the radical initiator and aryl source, realizing arylation of quinoxalin-2(1H)-one in a one-step reaction. The methodology has the advantages of being a metal-free strategy and having broad functional group tolerance.
- Subjects :
- metal-free
Materials Science (miscellaneous)
Iodide
quinoxalin-2(1h)-one
010402 general chemistry
01 natural sciences
Peroxide
Catalysis
Coupling reaction
radical process
Biomaterials
chemistry.chemical_compound
iodide/peroxide system
QD1-999
chemistry.chemical_classification
010405 organic chemistry
Aryl
Organic Chemistry
c–h activation
Combinatorial chemistry
0104 chemical sciences
Chemistry
chemistry
Metal free
Functional group
Radical initiator
Subjects
Details
- ISSN :
- 25099396
- Database :
- OpenAIRE
- Journal :
- SynOpen
- Accession number :
- edsair.doi.dedup.....a122101c638cc8416131d400151f3378