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Presence of the point mutations Val1016Gly in the voltage-gated sodium channel detected in a single mosquito from Panama
- Source :
- Parasites & Vectors, Vol 12, Iss 1, Pp 1-7 (2019), Parasites & Vectors
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background In Panama, arboviroses such as dengue fever, and more recently chikungunya fever and Zika disease, are transmitted by Aedes aegypti and Aedes albopictus. Their control is based on the elimination of breeding sites and fogging with pyrethroid insecticides. However, one of the significant issues derived from the prolonged use of pyrethroid insecticide is the development of resistance mechanisms, such as knockdown resistance or kdr. The objective of this study was to evaluate the presence of kdr mutations in a partial region of the VGSC gene in samples of wild-caught Aedes mosquitoes from different locations of the Metropolitan Region of Panama. Results Based on the analysis of 194 sequences of the VGSC gene, two kdr mutations (Ile1011Met and Val1016Gly) were detected in a specimen of Ae. aegypti. The frequency of kdr mutations in the evaluated samples of Ae. aegypti was 0.01. Conclusions This study provides evidence for a low frequency of kdr mutations in Ae. aegypti populations in Panama. It is possible that these changes have no impact on vector control interventions. To our knowledge, we report, for the first time in America the Val1016Gly mutation documented in Asia. In general terms, this result is highly relevant to the Aedes Control Programme in Panama since it constitutes a feasible approach for the timely detection of resistance as well as for the development of strategies. Electronic supplementary material The online version of this article (10.1186/s13071-019-3309-y) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Insecticides
Pyrethroid resistance
Aedes albopictus
Panama
Drug Resistance
Aedes aegypti
Review
Mosquito Vectors
Voltage-Gated Sodium Channels
Dengue fever
lcsh:Infectious and parasitic diseases
Dengue
chemistry.chemical_compound
Aedes
Pyrethrins
parasitic diseases
medicine
Voltage-gated sodium channel
Animals
Point Mutation
lcsh:RC109-216
Pyrethroid
biology
Zika Virus Infection
Point mutation
virus diseases
Knockdown resistance
biology.organism_classification
medicine.disease
Virology
Infectious Diseases
chemistry
Amino Acid Substitution
Chikungunya Fever
Parasitology
Female
kdr mutations
Subjects
Details
- Language :
- English
- ISSN :
- 17563305
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Parasites & Vectors
- Accession number :
- edsair.doi.dedup.....a11eee2987370192e23efee4393cf14a