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Interactions of FGFs with target cells
- Publication Year :
- 1992
- Publisher :
- HAL CCSD, 1992.
-
Abstract
- Growth factors play a key role in cellular communication, a necessary step for the development of pluricellular organisms. The fibroblast growth factors (FGF) are among these polypeptides and have seven known members: FGF 1 to FGF 7 which are also known as acidic FGF, basic FGF, translation products of oncogenes hst, int 2, FGF 5, FGF 6 and FGF 7 or keratinocyte growth factor (KGF) respectively [1]. The best known and the most abundant in normal adult tissues are acidic and basic FGFs, or FGF 1 and 2 respectively, which have been subjected to extensive studies both in vitro and in vivo. These two factors have almost ubiquitous distribution and a wide spectrum of biological activity including action on cellular proliferation and differentiation, as well as neurotrophic and angiogenic properties [1]. These different activities are induced by triggering specific receptors present at the surface of the target cell. Following this interaction, the FGF-receptor complexes are internalized and activate intracellular pathways. An important effort of investigations has been produced to characterize these receptors and intracellular pathways. It is the purpose of this review to present this work which will focus on FGFs 1 and 2. The existence of two classes of interactions has been reported as early as 1987 [52, 53, 54] suggesting the presence of high and low affinity receptors for FGFs.
- Subjects :
- medicine.medical_treatment
Cell
Biology
Fibroblast growth factor
chemistry.chemical_compound
medicine
Animals
Humans
Tissue Distribution
RNA, Messenger
Receptor
Binding Sites
Growth factor
Translation (biology)
General Medicine
Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors
[SDV] Life Sciences [q-bio]
Kinetics
medicine.anatomical_structure
chemistry
Biochemistry
biology.protein
Keratinocyte growth factor
General Agricultural and Biological Sciences
Intracellular
Signal Transduction
Neurotrophin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a1148bfa01baf9ba0e682c5ac9c0d86f