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Topology and hemodynamics of the cortical cerebrovascular system
- Source :
- Journal of Cerebral Blood Flow & Metabolism
- Publication Year :
- 2012
-
Abstract
- The cerebrovascular system continuously delivers oxygen and energy substrates to the brain, which is one of the organs with the highest basal energy requirement in mammals. Discontinuities in the delivery lead to fatal consequences for the brain tissue. A detailed understanding of the structure of the cerebrovascular system is important for a multitude of (patho-)physiological cerebral processes and many noninvasive functional imaging methods rely on a signal that originates from the vasculature. Furthermore, neurodegenerative diseases often involve the cerebrovascular system and could contribute to neuronal loss. In this review, we focus on the cortical vascular system. In the first part, we present the current knowledge of the vascular anatomy. This is followed by a theory of topology and its application to vascular biology. We then discuss possible interactions between cerebral blood flow and vascular topology, before summarizing the existing body of the literature on quantitative cerebrovascular topology.
- Subjects :
- medicine.medical_specialty
Neurology
Vascular anatomy
Clinical Neurology
Hemodynamics
10050 Institute of Pharmacology and Toxicology
610 Medicine & health
Review Article
Biology
Topology
Energy requirement
2705 Cardiology and Cardiovascular Medicine
03 medical and health sciences
0302 clinical medicine
medicine
cerebral hemodynamics
Animals
Humans
Topology (chemistry)
030304 developmental biology
0303 health sciences
Vascular biology
Brain
vascular biology
Neurodegenerative Diseases
cerebrovascular disease
Functional imaging
2728 Neurology (clinical)
Cerebral blood flow
Cerebrovascular Circulation
2808 Neurology
570 Life sciences
biology
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Neuroscience
Blood Flow Velocity
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....a113917ccd622ac6bd65c61f92f9720c